摘要
目的:探讨抗精神病药联用西酞普兰治疗精神分裂症阴性症状的疗效。方法:以阴性症状为主的住院精神分裂症39例,在原用抗精神病药基础上,联用西酞普兰治疗。疗程12周。使用阳性与阴性症状量表(PANSS)和治疗中出现的症状量表(TESS),在治疗前和治疗4、8、12周末各评定1次。结果:联用西酞普兰12周后,PANSS总分、阴性症状因子分及情感迟钝、情感退缩、情感交流障碍、被动/淡漠及社交退缩分均比治疗前显著降低。结论:以阴性症状为主的精神分裂症,在使用抗精神病药物的同时联用西酞普兰,对改善阴性症状有明显效用。
Objective： To explore the efficacy of antipsychotics combined with citalopram in the treatment of negative symptoms of schizophrenia. Method：39 schizophrenic inpatients with negative symptoms were treated with antipsychotics combimed with citaloprom. Positive and negative symptom scale（PANSS） and treatment emergent symptom scale （TESS） were used to assess the efficacy and side effects before and after treatments at the end of 4th, 8th, 12th week. Results：After 12 weeks of treatments, the total scores and negative factor,emotional blunting,emotional withdrawal, emotional exchange disorder, passive/ apathy, and social withdrawal factors of PANSS decreased significantly. Conclusion： Antipsychotics combined with citalopram can improve negative symptoms in patients with schizophrenia .
出处
《临床精神医学杂志》
2009年第1期46-47,共2页
Journal of Clinical Psychiatry
