摘要
目的：探讨恶性胶质瘤术后联合应用卡氮芥、甲氨喋呤杀灭残余的肿瘤组织和细胞的作用。方法：根据显微手术切除程度，将２９例恶性胶质瘤患者分为Ａ组（全切）１３例和Ｂ组（大部切除）１６例，均采用甲氨喋呤１００ｍｇ术中瘤床处理及残余瘤内注射和术后卡氮芥每次动脉灌注２～３ｍｇ／ｋｇ合并每次椎管内注射甲氨喋呤４０ｍｇ治疗，每６周重复１次。结果：２９例均连续随访，１２、２４、３６个月生存数Ａ组分别为１２／１３、１１／１３、８／１３，Ｂ组分别为１４／１６、１１／１６、８／１６。结论：这种联合化疗方法可以明显提高恶性胶质瘤患者术后生存时限。
Objective: To observe the effectiveness of postoperative combination carmustine(BCNU) with methotrexate(MTX) chemotherapy for treatment of malignant glioma to prolong the patients' life and improve the quality of life. Methods: 29 patients with malignant glioma who underwent surgical resections. According to the completion of the resection the patients were classifed into group A and group B. During the operation, after the removal of the tumor, injection of 100 mg MTX with 5 ml natrii chloridum into residual tumor tissues, suspectable places and tumor bed was accomplished and covering the tumor bed with thin gelatin sponges was undertaken. After operation, superselective intraarterial perfusion with BCNU 2～3 mg/kg and spinal canal injection with MTX 40 mg one times were carried out and repeated every 6 weeks. Results: The survival rate of 12, 24 and 36 months in group A was 12/13、11/13、8/13 respectively and was 14/16、11/16、8/16 in group B. Conclusion: The combined chemotherapy could prolong the postoperative patients' life.
出处
《北京医科大学学报》
CSCD
1998年第2期172-173,179,共3页
Journal of Peking University(Health Sciences)
关键词
脑肿瘤
胶质瘤
术后
药物疗法
卡氮芥
甲氨喋呤
Glioma/drug ther Methotrexate/ther use Carmustine/ther use Postoperative period
