摘要
目的：观察放射治疗对骨转移癌疼痛的缓解效果。方法：78例患者102处骨转移灶，采用直线加速器6MV—X治疗。随机分成3组，常规分割组：25例33处，2Gy做，5d／周，DT40--50Oy／4～5周；大分割组：26例32处，3Gy／次，5d／周，DT30～36Gy／2～3周；混合分割组：27例37处，3Gy／次，连续照射5d后改为常规分割，DT35--45Gy／4～5周。结果：常规组有效率87．9％，大分割组有效率93．8％，混合组有效率94．6％。3组总有效率为92．2％，但3组不同分割方式对疼痛缓解无差异，P〉0．05。3组放疗副反应的发生机率相近，且症状较轻。结论：放射治疗对骨转移癌疼痛是一种好的止痛方法，常规分割、大分割、混合分割3组放射治疗止痛疗效和放疗副反应相近。
Objective：To observe the analgesic effect of radiotherapy in relieving pain caused by metastatic bone tumors. Methods ： 78 patients （102 metastases） undergone irradiation with linear accelerator 6MV-X were randomized into group of conventional fractionated irradiation （group A, 25 cases with 33 metastases）, larger fractionated dosage （group B, 26 case with 32 metastases） and combined fractionated irradiation（group C, 27 cases with 37 metastases）. Group A received the irradiation at a dose of 2 Gy/fraction daily （5 days/week）with a total dosage range of 40 to 50 Gy in 4 to 5 weeks, group B underwent irradiation at a dose of 3 Gy/fraction daily（5 days/week） with a dosage range of 30 to 36 Gy in 2 to 3 weeks and group C were given at a dose of 3 Gy/fraction daily in the initial consecutive five days followed by conventional radiotherapy with a total dosage of 35 to 45 Gy in 3 to 4weeks. Results： The analgesic effect of radiotherapy was found in 87.9% of the patients in group A, and that was 93.8% in group B and 94.6% in group C, with an average of 92.2% in the three groups. The different fractionated dose gave no difference with regard to pain relid and side effects. Conclusion ： Radiotherapy is favorable in relieving the pain induced by metastatic bone tumors and the models of fractionated irradiation produce no difference in effect or side effect.
出处
《皖南医学院学报》
CAS
2009年第1期34-36,共3页
Journal of Wannan Medical College
关键词
骨转移癌
放射治疗
疼痛
bone metastasis
radiotherapy
pain
