摘要
杂环芳香酸和手性氨基醇通过缩合反应制备了9个新型手性有机小分子催化剂(3a^3 i),其结构经1H NMR,13C NMR和MS表征。3用于催化α-酮亚胺基酯的不对称氢化硅烷化反应(三氯硅烷为还原剂),可得到高收率和中等对映选择性的手性α-氨基酸酯。
Nine novel organic catalysts（3a - 3i） were synthesized by condensation between aromatic acid and chiral aminoalcohols. The structures were characterized by ^1H NMR, ^13C NMR and MS. 3 was used as a catalyst in asymmetric hydrosilylation（ trichlorosilane as a reducer） of α-ketiminoesters to obtain chiral α-amino esters in high yields and moderate enantioselectivities.
出处
《合成化学》
CAS
CSCD
北大核心
2009年第1期19-22,27,共5页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(20572109,20772122)
四川省青年科技基金资助项目
