摘要
为了评价钼的生物毒性,用钼酸铵对小鼠进行中毒试验。通过腹腔注射剂量分为600、720、863、1 0361、244 mg/kg的(NH4)6Mo7O24.4H2O,48 h统计死亡率并计算LD50;32只小鼠分为4组,分别在饮水加入含0、80、1001、20 mg/L的(NH4)6Mo7O24.4H2O,每隔3 d称重,7 d后进行血液学和病理学分析。结果腹腔注射的LD50为813.264 mg/kg±0.0426 mg/kg;饮水中毒试验5 d时各剂量组均表现严重中毒症状,中毒小鼠尸体消瘦,小肠壁出血并有红白相间花斑,肾脏体积肿大,肝脏肿大发生脂肪变性;血液稀薄,血细胞压积降低,红细胞数和血红蛋白量减少,精子畸形率显著增加。表明钼酸铵对小鼠属于中等毒性,可造成贫血、组织脏器病变及精子畸形等。
To estimate the molybdenian biological toxicity,this experiment researched the effect of molybdenum on mice. Ammonium molybdate was injected intraperitoneally or drinked in water. The concentrations of ammonium molybdate by injecting were 600, 720, 863, 1 036 and 1 244 mg/kg,respectively. The mortalities was recorded within 48 h and LD50was calculated. The concentrations by drinking were 0, 80, 100, 120 mg/kg. The changes of blood, pathological lesions and sperm abnormality were detected after 7 days. The results showed that the LD50 of intraperitoneally injected ammonium molybdate in mice was 813. 264 mg/kg±0.042 6 mg/kg. The mice in all group showed poisoning symptoms and pathological lesions at the fifthe day, including weight loss, liver enlargement and fat denaturation, enlarged kidneys, hemorrhage in small intestine thinner blood, reduced erythrocytes, hemoglobin and packed cell volume,increased sperm abnormality rate. These results indicated that ammonium molybdate are moderately toxic in mice, molybdenum can cause anemia, pathological lesions in internal organs and sperm abnormality.
出处
《动物医学进展》
CSCD
北大核心
2009年第2期56-60,共5页
Progress In Veterinary Medicine
关键词
小鼠
钼酸铵
中毒
血液学
mouse
ammonium molybdate
poisoning
hematology
