摘要
目的观察普米克令舒和万托林联合雾化吸入对慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法60例AECOPD患者随机分为两组:观察组32例、给予普米克令舒1mg和万托林雾化液1ml联合雾化吸人治疗,2次/d;对照组28例、给予万托林雾化液1ml雾化吸人治疗,2次/d,地塞米松10mg静脉滴注,FEV1观察疗效及不良反应。结果两组患者治疗后临床症状评分均明显降低,FEV1和PEF及pH值、PaO2、PaCO2均有改善,治疗前后相比差异有统计学意义(P<0.05),但两组间相互比较差异无统计学意义(P>0.05);观察组不良反应明显少于对照组。结论普米克令舒和万托林联合雾化吸入能够改善AECOPD患者肺功能及临床症状,与全身使用糖皮质激素疗效相近,但不良反应明显减少。
Objective To observe the clinical effect of pulmicort repulse plus ventolin inhalation on acute exacerbation of chronic obstructive pulmonary disease. Methods 60 patients with AECOPD were randomly divided into two groups ： the observed group of 32 patients were given the treatment of pulmicort repulse （1 mg） plus ventolin inhalation of foggy twice a day; the control group of 28 pa- tients were given the treatment of ventolin inhalation of foggy twice a day and injection of dexamethasone （ 10 mg） once a day. The change of FEV1 , PEF, pH, PaO2, PaCO2 on the first day and the eventh day was recorded, meanwhile observed the side effect as well as the effect analysis. Results After treatment, the clinical symptom scores of the two groups were ameliorated significantly , and there was no significant difference between 2 groups （P 〉0.05）. FEV1 , PEF, pH, PaO2 , PaCO2 of 2 groups were improved, and there was significant difference after the treatment（P 〈0. 05）, but there was still no significant difference between 2 groups （P 〉0. 05） ; The side effect of the observed group was significantly less than that of the control group. Conculsion The treatment of pulmicort repulse plus ventolin inhalation can improve the lung function and the clinical symptom of patients with AECOPD, which is similar to the effect of intravenous glucocorticoid, but has less adverse effect.
出处
《临床肺科杂志》
2009年第3期321-322,共2页
Journal of Clinical Pulmonary Medicine
关键词
普米克令舒
万托林
雾化吸入
慢性阻塞性肺疾病急性加重期
Pulmicort repulse, Ventolin, Inhalation of foggy, Acute exacerbation of chronic obstructive pulmonary disease
