摘要
目的评价血清N末端脑钠肽(NT-proBNP)定量检测对心力衰竭患者的诊断价值。方法采用定量ELISA改进法检测不同心衰程度的患者血清NT-proBNP。结果心衰患者血清NT-proBNP水平明显增高,并随心衰患者程度加重呈指数增加;实验受试者工作特征曲线下面积为0.898;心衰的诊断敏感性和特异性分别为91.9%和92.3%。结论定量检测血清NT-proBNP是目前用于评价心衰患者的最佳实验手段。
Objective To evaluate the diagnostic value of N terminal pro brain natriuretic peptide （NT-proBNP） quantitative detection in patients with heart failure. Methods Quantitative enzymelinked immunosorbent assay （ELISA） improvement method was applied to measuring serum level of NT-proBNP in patients with different degree of heart failure. Results The serum level of NT-proBNP was significantly elevated in patients with heart failure. With the increase of extent of heart failure, NT-proBNP increased in exponent. Receiver operator characteristic curve （ROC） showed that area un der curve （AUC） was 0. 898. The sensitivity and specificity were 91.90% and 92.3% respectively for diagnosis of heart failure. Conclusion Quantitative detection of NT proBNP is at present the best laboratory test for evaluating heart function of patients with heart failure.
出处
《国际检验医学杂志》
CAS
2009年第1期23-25,共3页
International Journal of Laboratory Medicine
关键词
利钠肽
脑
心力衰竭
充血性
诊断
Natriuretic peptide,brain
Heart failure,congestive
Diagnosis
