摘要
目的通过分析慢性乙型肝炎（chronic hepatitisB，CHB）患者干扰素治疗过程中网织红细胞（reticulocyte，Ret）参数变化情况，了解骨髓造血功能。方法采用血细胞分析仪检测78例慢性乙型肝炎患者外周血白细胞（WBC）及中性粒细胞绝对值（ANC），网织红细胞百分比（Ret％）、网织红细胞计数绝对值（Ret#）及未成熟网织红细胞指数（IRF）。30例健康体检者作为正常对照组。结果CHB患者干扰素治疗2w后，Ret％，Ret#，IRF显著低于对照组；WBC，ANC于治疗4W后开始显著减低；IRF在治疗结束后1w开始恢复，Ret％，Ret#在治疗结束后2w开始恢复，WBC，ANC治疗结束后4w开始恢复。结论Ret各参数可用于了解CHB患者干扰素治疗后骨髓抑制情况，其敏感度高于WBC和ANC。
Objective To investigate the change of reticulocyte parameters：reticulocyte percent （RET%）,absolute reticuloeyte count （RET # ） ,immature reticulocyte fraction （IRF） in chronic hepatitis B with IFN treating. Methods White blood cell （WBC） and reticulocyte parameters was measured automatically by Beckman-coulter LH-750 analyzer. Results The change of reticulocyte parameters has significant difference （P〈0. 01） after two weeks in chronic hepatitis B with IFN treating ;one week after stop treating,IRF was normal;two weeks after stop treating RET % and RET# was normal. Conclusion The change of retieuloeyte parameters is very important in chronic hepatitis B with IFN treating.
出处
《现代检验医学杂志》
CAS
2009年第1期136-137,共2页
Journal of Modern Laboratory Medicine
