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冠心病患者血清组织蛋白酶L的变化及其与高敏C反应蛋白的相关性 被引量:10

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摘要 目的:探讨冠心病患者组织蛋白酶L(cathepsin L,CatL)水平的变化及其与炎症因子高敏C反应蛋白(hs-CRP)之间的关系。方法:测定137例冠心病患者(冠心病组)和48例非冠心病患者(对照组)的血清CatL水平和hs-CRP水平。结果:冠心病组、对照组的hs-CRP分别为(10.28±1.73)、(1.72±0.39)mg/L,2组比较,差异有统计学意义(P<0.01);冠心病组、对照组的CatL水平分别为(5.63±0.12)、(3.93±0.22)μg/L,2组比较,差异亦有统计学意义(P<0.01)。CatL与hs-CRP的相关性分析显示相关系数为0.339,P<0.01。结论:CatL可能与粥样斑块的破裂相关,CatL与hs-CRP呈显著正相关。
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2008年第12期944-946,共3页 Journal of Clinical Cardiology
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参考文献12

  • 1LIU J, SUKHOVA G K, YANG J T, et al. Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells [J]. Atherosclerosis, 2006,184 : 302 - 311. 被引量:1
  • 2SOFIA J, DIRK M W, ALLAN S, et al. Differential expression of cysteine and aspartie proteases during progression of atherosclerosis in apolipoprotein E-deficient mice[J]. Am J Pathol,2002,161:939-945. 被引量:1
  • 3LI W, YUAN X M. Increased expression and translocation of lysosomal cathepsins contribute to macrophage apoptosis in atherogenesis[J]. Ann N Y Acad Sci, 2004,1030:427-433. 被引量:1
  • 4KITAMOTO S, SUKHOVA G K, SUN J, et al. Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor knockout mice [J]. Circulation, 2007,115:2065 - 2075. 被引量:1
  • 5FACH E M, GARULACAN L A, GAO J, et al. In vitro biomarker discovery for atherosclerosis by proteomics[J]. Mol Cell Proteomies, 2004, 3: 1200- 1210. 被引量:1
  • 6文美,毛华,陈晶晶,刘庭筑,须五平,李莉佳.冠心病患者介入治疗后不同时期白细胞介素-8、C反应蛋白及血浆P选择素的变化[J].临床心血管病杂志,2006,22(1):25-27. 被引量:7
  • 7NORJA S, NUUTILA L, KARHUNEN P J, et al. C reactive protein in vulnerable coronary plaques[J]. J Clin Pathol, 2007,60 : 545-548. 被引量:1
  • 8VILLADANGOS J A, BRYANT R A, DEUSSING J, et al. Proteases involved in MHC class Ⅱ antigen presentation[J]. Immunol Rev, 1999,172 : 109 --120. 被引量:1
  • 9JOYCE JA, BARUCH A, CHEHADE K, et al. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis[J]. Cancer Cell, 2004,5 : 443- 453. 被引量:1
  • 10VONEND O, APEL T, AMANN K, et al. Modulation of gene expression by moxonidine in rats with chronic renal failure [J].Nephrol Dial Transplant,2004,19:2217-2222. 被引量:1

二级参考文献8

  • 1张涛,李自成.冠心病易损斑块的研究进展[J].临床心血管病杂志,2004,20(8):509-512. 被引量:18
  • 2周同.细胞粘附分子的研究进展[J].上海免疫学杂志,1995,15(1):58-61. 被引量:22
  • 3KUVIN J T, KIMMELSIEL C D. Infection causes of atherosclerosis [J]. Am Heart J, 1999, 137: 216-226. 被引量:1
  • 4CREA F, BIASUCCI I. M, BUFFON A, et al. Role of inflammation in the pathogenesis of unstable coronary artery disease[J]. Am J Cardiol, 1997,80:10E-16E. 被引量:1
  • 5WEINBRENNER T, CLADELLAS M, LSABEL CM, et al. High oxidative stress in patients with stable coronary heart disease [J]. Atherosclerosis, 2003,168:99-106. 被引量:1
  • 6LINDSAY C D, MICHAEL P S, LINDA J B , et al.Characterization of GMP-40 (P-selectin) as a circulating plasma protein [J]. J Exp Med, 1992, 175:1147-1150. 被引量:1
  • 7HARB T S, ZAREDA W, MOSS A J, et al. Association of C-reactive protein and serum amyloid A with recurrent coronary events in stable patients after healing of acute myocardial infarction [J]. Am J Cardiol,2002, 89:216-221. 被引量:1
  • 8ALLEN P B, RUSSELL P T, FRANK K, et al. Elevated C reactive Protein values and atherosclerosis in sudden coronary death; Association with different pathologies [J]. Circulation, 2002, 17:2019-2029. 被引量:1

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