摘要
目的：介绍应用紫外分光光度法测定米非司酮血药浓度的方法。方法：以氯仿为提取液，甲醇为溶媒，在３０４ｎｍ处进行测定。血浆标准曲线线性范围４～２４μｇ·ｍｌ－１（ｒ＝０．９９９７）。结果：平均回收率（９３．３±４．６）％，ＲＳＤ日内（２．１±０．８）％，ＲＳＤ日间（３．１±０．４）％。应用该法对１０例孕妇进行米非司酮血药浓度测定，其浓度在１０～２０μｇ·ｍｌ－１之间。结论：分析结果表明该方法简便可行。
etermination of mifepristone in plasma by UV spectrophotometry was described. Trichloromethane was used as extraction solvent, methyl alcohol as solvent. The linear range was 4-24 μg·ml -1 ( r = 0.999 7 ). The average recovery was ( 93.3 ± 4.6 )%, The RSD of within day was 2.1% , and between day was 3.1% . UV detection wavelength was 304 nm. The results showed that this method was simple and feasible.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1998年第6期262-263,共2页
Chinese Journal of Hospital Pharmacy
关键词
米非司酮
紫外分光光度法
血药浓度
mifepristone, UV spectrophotometric method, blood concentration
