摘要
目的:探讨纤溶酶原激活物抑制剂-1(PAI-1)4G/5G基因多态性与天津及河北地区汉族人群中妊娠期糖尿病(GDM)发病及胰岛素抵抗(IR)的相关性。方法:用PCR方法检测GDM组和正常妊娠对照组(每组75例)PAI-1 4G/5G基因型,并分析相关临床资料。结果:GDM组4G/4G基因型频率及4G等位基因频率均高于正常对照组(P<0.05)。GDM组4G/4G基因型孕妇空腹胰岛素、胰岛素抵抗指数均高于5G/5G组(P<0.05)。结论:PAI-1 4G/5G基因多态性与GDM发病相关,4G/4G基因型可能是GDM的易感基因;PAI-1 4G/4G基因型与GDM患者IR的发生有关。
Objective：To investigate the association of PAI-1 4G/SG gene polymorphism with gestational diabetes patients and insulin resistance in Han nationality women of China. Methods ：The genotypes of PAI-1 4G/SG variants were determined by polymerase chain reaction （PCR） assay both in women with GDM and pregnant women with normal glucose tolerance （n = 75 for each group ）. Fasting blood glucose, fasting insulin were also analyzed. Results：4G/4G genotype frequency and 4G allele frequency were higher in women with GDM compared with control group（P 〈 0. 05 ）. In GDM group, PAI-1 4G/4G genetype-carryiug subjects showed higher level of fasting serum insulin,insulin resistance index compared with 5G/SG genetype-carrying subjects （P 〈 0.05）. Conclusion： PAI-1 4G/SG polymorphism correlates with the pathogenesis of GDM,suggesting that PAI-1 4G/4G homozygotes is a susceptible gene of GDM. In GDM patiens, PAI-1 4G/4G genetype is one of high risk genetic factors to insulin resistance.
出处
《现代妇产科进展》
CSCD
北大核心
2008年第12期913-915,919,共4页
Progress in Obstetrics and Gynecology
