摘要
目的总结同心圆硬化的MRI及弥散加权成像（DWI）特点，并探讨其影像学变化与可能发生机制的相关性。方法总结临床确诊的同心圆硬化患者3例，均行头颅MRI及DWI检查，其中1例患者行氢质子波谱成像（^1H—MRS）。结果3例患者均为多发病灶，病灶多位于中央白质区，均可见特征性的“同心圆样”或“洋葱皮样”改变，增强扫描呈环形或半环形强化。DWI见病灶呈高、低交替环形信号，表观扩散系数（ADC）值随同心圆病理的脱髓鞘区与髓鞘保留区相间存在而出现高低相间变化。结论Balo同心圆硬化MR!和DWI表现具有特征性，可与病理改变对应，为加深该病发生机制认识提供影像学证据。
Objective To sum up the magnetic resonance imaging （MRI） and diffusion-weighted imaging （DWI） characters in patients with concentric sclerosis, and to investigate the association between imaging and possible pathogenesis. Methods Three patients with clinically diagnosed concentric sclerosis underwent MRI and DWI, one of whom was additionally performed ^1H-magnetic resonance spectroscopy imaging （1H-MRS）. Results Multiple lesions of laminated demyelination alternating with spared white matter were demonstrated in all 3 patients, and the enhanced lesions appeared to be concentric coils. Rings of alternating hypointense and hyperintense layers were shown on the DWI image, with apparent diffusion coefficient alternating correspondingly to the layers of the histologically demyelinated and undemyelinated areas. Condusions Balo＇ s concentric sclerosis has unique characteristics on MRI and DWI, which corresponds to changes in its pathology and provides evidence for a better understanding of its pathophysiologic mechanisms.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2009年第1期25-29,共5页
Chinese Journal of Neurology
关键词
Schilder弥漫性脑硬化
磁共振成像
磁共振成像
弥散
Diffuse cerebral sclerosis of Schilder
Magnetic resonance imaging
Diffusion magnetic resonance imaging
