摘要
目的:探讨诱导型一氧化氮合酶(iNOS)在糖尿病大鼠视网膜组织中的表达及其对细胞凋亡的影响。方法:建立糖尿病大鼠动物模型,分别在成模后第1,3,6mo时测定大鼠视网膜组织细胞凋亡指数(AI)和iNOS表达水平。结果:(1)与正常对照组(NC)相比,iNOS表达在糖尿病各组均升高,6mo时明显增强(P<0.05);(2)视网膜细胞凋亡情况:与正常对照组(NC)相比,糖尿病模型1mo时细胞凋亡指数差异无统计学意义,3,6mo时则明显升高(P<0.05)。结论:iNOS在糖尿病大鼠视网膜组织中的表达增强,推断iNOS在糖尿病视网膜病变(retinopathy of diabetes,DR)的发病机制中起一定作用。
AIM： To investigate the expression of inducible nitric oxide （iNOS） and its effection on the apoptosis of retina in diabetic rats. METHODS： The model of diabetes was induced by streptozotocin. The apoptotic index （AI） of retina and iNOS were observed at 1, 3 and 6 months during the experiment, respectively. RESULTS： The expression of iNOS of retina in diabetic rats was markedly higher than NC in 6-month group （ P〈 0.05）. Compared with NC, AI was significantly higher in 3 and 6-month groups （P〈 0.05）. Compared with NC, AI had no significantly difference in 1-month group. CONCLUSION： The expression of iNOS of retina in diabetic rats is higher. It may act an important role in the retinopathy of diabetes.
出处
《国际眼科杂志》
CAS
2009年第1期47-48,共2页
International Eye Science
