摘要
除线粒体外,过氧化物酶体也是真核细胞脂肪酸β氧化分解的重要部位.过氧化物酶体β氧化过程包括氧化、加水、脱氢和硫解4步反应,主要参与极长链、支链脂肪酸等的分解.近年关于过氧化物酶体β氧化的研究活跃,在代谢途径及功能等方面有了新的认识,尤其在对相关代谢酶的研究中取得了较大进展.本文就过氧化物酶体β氧化相关进展作一综述.
Besides mitochondria, peroxisomes are subcellular organelles that are capable of conductmg β- oxidation of fatty acids in eukaryocytes. Peroxisomal fatty acid β-oxidation consists of four sequential enzymatic steps （oxidation, hydratation, dehydrogenation, and thiolytic cleavage）, and results in the degradation of long-chain fatty acids or 2-methyl-branched fatty acids. In recent years, studies on peroxisomal fatty acid β- oxidation have become an active research focus, and substantial progresses have been made, especially for the metabolic enzymes. This article will review the recent advances in aspects of the functional characteristics, metabolic enzymes, regulation, and deficiencies of peroxisomal fatty acid β-oxidation.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2009年第1期12-16,共5页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家自然科学基金资助项目(No.30371566)~~
