摘要
目的探讨中医院大肠埃希菌的感染现状和耐药性变迁，为临床医师合理使用抗菌药物提供理论依据。方法病原菌分离鉴定按《全国临床检验操作规程》进行，用NCCLS／CLSI推荐的K—B法作体外耐药临测和评价结果。结果4年中，大肠埃希菌对17种常用抗菌药物的耐药率总体呈上升趋势，其中，以氨苄西林耐药率最高，达90．8％～94．2％，而亚胺培南和美罗培南尚未出现耐药菌株；产超广谱G-内酰胺酶（ESBLs）大肠埃希菌的检出率由13．2％上升到32．0％。结论中医院大肠埃希菌的耐药问题已非常严重，临床应加强合理使用抗菌药物管理，严格控制耐药菌的产生和医院感染暴发流行。
OBJECTIVE To investigate drug-resistance status and changing tendency of Escherichia coli in traditional Chinese medicine hospital to provide the evidence for reasonable use of antibiotics. METHODS Pathogenic bacteria were isolated and identified according to the National Clinical Laboratory Operation Rules. Drug resistance profile was analyzed by K-B methods. RESULTS In the four years, the resistance to seventeen commonly used antibiotics in E. coli was on the rise. The resistance rate to ampicillin was the most highest （90.8- 94.2%）. No strain was resistant to imipenem and meropenem, the detection rate of extended spectrum l]- lactamases （ESBLs） producing E. coli was increasing from 13. 2% to 32. 0%. CONCLUSIONS Drug-resistance status of E. coli in traditional Chinese medicine hospital is very serious. We should strengthen the management of antibiotic use and control the spread and prevalence of the drug-resistant bacteria.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第2期214-216,共3页
Chinese Journal of Nosocomiology
关键词
大肠埃希菌
超广谱Β-内酰胺酶
医院感染
耐药性
Escherichia coli
Extended spectrum β-lactamases （ESBLs）
Nosocomial infection
Drug-resistance
