摘要
目的评价神经生长因子治疗轻、中度老年痴呆的疗效。方法选择68例轻、中度老年痴呆患者随机分为实验组和对照组。对照组给予常规治疗,实验组在常规治疗的基础上每日加用18μg神经生长因子注射液。以临床痴呆程度量表(CDR)、简易智能状态量表(MMSE)、日常生活自理量表(ADL)、老年痴呆患者生活质量量表(QOL)等评分作为主要评价指标,比较2组患者在治疗前及治疗后第4、第8周认知能力、生活质量、日常生活能力的改善情况。结果实验组患者CDR、MMSE、ADL、QOL评分优于对照组,临床症状显著改善,差异有显著性意义(P<0.05)。结论神经生长因子治疗轻、中度老年痴呆有效。
Objective To evaluate the curative effect of nerve growth factors on mild and moderate senile dementia. Methods A total of 68 patients with mild or moderate senile dementia were randomly divided into a control group and a study group. The control group received conventional therapy, while the study group were administrated inter-vascularly with 18 microgram of nerve growth factors every day in addition to conventional therapy. The improvement of recognition ability, quality of life , activities of daily life were graded by Mini-mental state examination （MMSE）, Clinic dementia rating scale （CDR）, Activities of daily living （ADL） and Quality Of Life （QOL）. The scores were compared between the groups before treatment, 4 weeks and 8 weeks after the treatment respectively. Results The scores of MMSE. CDR, ADL and QOL significantly improved in the study group compared with those of the control group （P〈0.05）. Conclusion Nerve growth factors could treat elderly patients with mild or moderate senile demen- tia effectively.
出处
《中南药学》
CAS
2009年第1期65-68,共4页
Central South Pharmacy
