摘要
雷帕霉素(rapamycin)是近年来应用较多的免疫抑制剂,它在肿瘤治疗中也发挥重要作用。雷帕霉素(rapa-mycin)与FKBP12结合,形成Rapamycin-FKBP12复合物,这一复合物抑制mTOR的活性,进一步抑制mTOR下游的一系列分子的合成或功能。雷帕霉素可将免疫细胞滞留于G1期,阻止免疫细胞的增殖;抑制IL-2和其他的免疫分子的合成,从而发挥其免疫抑制作用。另一方面,对于肿瘤细胞,雷帕霉素抑制其生长和增殖,发挥肿瘤抑制作用。它的这一双重功能可应用在器官移植和肿瘤治疗的交叉领域。
Rapamycin is frequendy used as an immunosuppressive agent and also plays an important role in tumor suppression. It combines to FKBP12 and forms a compound to inhibit the serine/threonine protein kinase mammalian target of rapamycin （roTOR） , its activation is required for protein synthesis and cell-cycle progression. Rapamycin can block cell cycle at G1 phase and to inhibit cell proliferation. Furthermore rapamycin may inhibit cytokine production and cytokine signaling. Therefore rapamycin is used in the treatment of post-transplantation organ rejection and tumor therapy due to its dual effects of immuno-suppression and tumor inhibition.
出处
《基础医学与临床》
CSCD
北大核心
2008年第12期1329-1331,共3页
Basic and Clinical Medicine
关键词
雷帕霉素
免疫抑制
肿瘤抑制
rapamycin
mTOR
immuno-suppression
tumor inhibition
