摘要
目的:研究甲磺酸帕珠沙星注射液对局部组织有无刺激性。方法:选用健康合格新西兰家兔,用甲磺酸帕珠沙星注射液进行局部刺激性试验。结果:甲磺酸帕珠沙星注射液对家兔眼结膜、虹膜、角膜均无刺激作用;肌肉解剖未见充血、水肿、变性或坏死,病理检查肌细胞结构正常;对心、肝、脾、肺、肾、耳缘、耳壳血管组织各分别不同地显示轻度扩张充血等。结论:甲磺酸帕珠沙星注射液对家兔眼结膜、虹膜、角膜均无刺激性;对肌肉组织无明显刺激性;对耳壳、耳血管、内脏血管均显示轻度血管刺激反应。
Objective： To study the irritant action of pazufloxacin mesylate injection to local tissue. Method： Pazufloxacin mesylate injection was given to local tissue of healthy rabbits. Result： There was not irritant action to the conjunctival, iris and cornea. The autopsy of muscle had no engorgement, degeneration and necrosis. There was slight engorgement and extand of the vessles of heart, liver, spleen, lung, kindey, and edge of ear. Conclusion： Pazufloxacin mesylate injection has no irritant action to the the eonjunctiva, iris and cornea of the rabbits. There isn＇ t irritant action to the muscle tissue. There are slight engorgement and extand to the vessles of the heart, liver, spleen, kidney, edge of ear and viscera.
出处
《中国药师》
CAS
2008年第12期1489-1490,共2页
China Pharmacist
关键词
甲磺酸帕珠沙星注射液
局部组织
刺激性
家兔
Pazufloxacin mesylate injection
Local tissue
Irritant action
Rabbits
