摘要
目的：为研究毫微粒给药系统质量评价，拓宽阿克拉霉素Ａ毫微粒的制剂学内容，制备了阿克拉霉素Ａ聚乳酸毫微粒。方法：采用均匀设计方法设计实验，以界面聚合法制备出阿克拉霉素Ａ聚乳酸毫微粒。结果：得到的毫微粒平均粒径为８０ｎｍ，平均载药量为１８．５％，平均包封率为８６．７％。结论：以聚乳酸为载体材料，制备阿克拉霉素Ａ聚乳酸毫微粒的工艺是可行的。
OBJECTIVE: To prepare the poly (DLlactide) aclacinomycin nanoparticle in order to evaluate the nanoparticle delivery system and to develop the pharmaceutics of aclacinomycin nanoparticle. METHODS: An optimal design was selected to establish the optimal condition, and the interfacial polymerization method was used to prepare the nanoparticle system. RESULTS: The mean diameter of the nanoparticle was 80 nm, the mean drug loading was 18.5%, and the drug embedding ratio was 86.7%. CONCLUSION: The technology of preparation of poly (DLlactide) aclacinomycin nanoparticle is practicable and successful.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1998年第5期289-291,共3页
Chinese Pharmaceutical Journal
基金
国家自然科学基金
