摘要
目的探讨非血液透析慢性肾功能衰竭(chronic renal failure,CRF)患者血清淀粉样蛋白A(serum amyloidA protein,SAA)水平与肾性贫血、肾性营养不良之间的关系。方法依据肾小球滤过率(glomerular filtrationrate,GFR)将62例CRF(CRF组)患者分为3个亚组:A组16例、B组18例、C组28例。采用酶联免疫吸附(ELISA)法检测各组患者血清SAA水平。并测定血常规、肝、肾功能。并与20例健康体检者(对照组)进行对比。结果CRF组血清白蛋白(Alb)、血红蛋白(Hb)水平均明显低于对照组(P均<0.01),A、B、C 3组血清SAA水平均显著高于对照组(P均<0.05)。相关分析结果显示,CRF患者血清SAA水平与Alb、Hb均呈负相关(r分别=-0.461、-0.643,P均<0.01)。结论非血液透析CRF患者存在血清SAA水平升高,这种微炎症状态可能通过不同的机制参与并加速了肾性贫血及肾性营养不良的发生。
Objective To elucidate the relationships between renal anemia,renal dystrophia and the levels of serum amyloid A protein（SAA） in patients with non-hemodialysis chronic renal failure（CRF）.Methods According to their levels of glomerular filtration rates（GFR）,62 non-hemodialysis CRF（CRF group）patients were divided into three sub groups： group A（16 subjects）,group B（18 subjects）,and group C（28 subjects）.Serum levels of SAA in CRF patients and 20 healthy controls（control group）were tested by ELISA.Hemogram,liver and renal functions in CRF patients and healthy controls were screened simultaneously.Results The levels of serum albumin（Alb）and haemoglobin（Hb） in CRF patients were significantly lower than those from controls group（all P〈0.01）.Serum levels of SAA in three groups of CRF patients were significantly higher than that in controls group（all P〈0.05）.Rank correlation analysis result demonstrated a negative correlation between serum levels of Alb and Hb and serum levels of amyloid SAA（r=-0.46,-0.6,all P〈0.01）.Conclusion The serum levels of SAA were remarkably increased in non-hemodialysis CRF patients.SAA may participate in the onsets of micro inflammatory status in patients with CRF,and accelerate the genesis of renal anemia and renal dystrophia.
出处
《实用临床医学（江西）》
CAS
2008年第12期28-30,共3页
Practical Clinical Medicine
