摘要
目的观察益气活血中药芪参益气滴丸对急性心肌梗死(AMI)后心室重构的疗效。方法90例AMI气虚血瘀型患者,随机分为芪参益气滴丸治疗组(n=46)和常规治疗对照组(n=44),治疗的第1、2周检测外周血白细胞(WBC)、C反应蛋白(CRP),第4、6周检测超声心动图指标及评价中医症状积分。结果治疗第1周时,治疗组WBC和CRP较对照组显著下降;第2周时两组WBC比较无显著性差异,治疗组CRP低于对照组,差异显著。治疗第4周,治疗组左室舒张末期内径(LVDd)、左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)较对照组减低,两组LV-EDV、LVESV比较差异显著,两组LVDd、左室射血分数(LVEF)比较差异不显著。治疗第6周,治疗组LVDd低于对照组,但两组间无显著性差异;治疗组LVEDV、LVESV较对照组低,两组之间有显著性差异;治疗组LVEF较对照组高,有显著性差异。中医症状积分:治疗第4、6周,治疗组较对照组积分降低,差异有统计学意义。结论芪参益气滴丸可降低外周血WBC和CRP水平,减轻AMI后炎症反应;抑制AMI后LVDd的扩大,降低LVEDV和LVESV,改善整体左室功能,且改善症状,具有一定的抗心室重构作用。
Objective To observe the curative effect of Qishenyiqi Gutta Pills on the ventricular remodeling after acute myocardial infarction. Methods All 90 patients with myocardial infarction of qi-deficiency and blood-stasis type were randomly divided into the treatment group treated with Qishenyiqi Gutta Pills （ n = 46） and the control group treated with routine therapy （ n = 44 ）. The levels of white blood cell （WBC） and C response protein （CRP） of peripheral blood were detected on the 1^st week and 2^nd week of the treatment. The indexes of ultrasound cardiography were detected and TCM symptom integrals were reviewed on the 4^th week and 6^th week. Results On the 1^st week the levels of WBC and CRP in the treatment group decreased significantly than those in the control group. On the 2^nd week there were no significant difference in WBC level between two groups, but CRP level in the treatment group was much lower than that in the control group with a significant difference. On the 4^th week the indexes, such as LVDd, LVEDV and LVESV in the treatment group reduced than those in the control group. The comparisons in LVEDV and LVESV between tow groups were different significantly but the differences of LVDd and LVEF between two groups were not significant. On the 6^th week LVDd in the treatment group was lower than that in the control group without significant difference, while LVEDV and LVESV in the treatment group were lower than thosr in the control group with a significant difference. LVEF in the treatment group was higher than that in the control group with a significant difference. TCM syndrome integrals in the treatment group reduced than those in the control group on the 4^th week and 6^th week, and the difference was significant statistically. Conclusion Qishenyiqi Gutta Pills can decrease the levels of WBC and CRP of peripheral blood, alleviate the inflammatory action, inhibit the enlargement of LVDd, reduce LVEDV and LVESV after myocardial infarction, improve the function of whole left ventrica
出处
《中国循证心血管医学杂志》
2008年第1期41-43,共3页
Chinese Journal of Evidence-Based Cardiovascular Medicine
基金
天津市自然科学基金资助(07JCZDJC08700)
天津市卫生局中西医结合科研专向基金资助(2005012)
关键词
心肌梗死
心室重构
芪参益气滴丸
Myocardial infarction
Ventrieular remodeling
Qishenyiqi Gutta Pills
