摘要
目的研究血管生成素-2（Ang．2）在食管鳞癌血管生成及肿瘤生长中的作用。方法应用免疫组织化学方法检测80例食管鳞癌和25例正常食管组织石蜡标本Ang-2和CD34表达，并以CD34标记的微血管计算组织的微血管密度（MVD）。结果食管鳞癌组织中Ang-2阳性表达率（70．00％，56／80）高于正常食管组织（24．00％，6／25）（P＜0．05），食管鳞癌组织中Ang-2表达与肿瘤组织学分级、浸润深度及淋巴结转移有关，与MVD呈正相关（r=0．603，P＜0．05），Ⅲ期和Ⅳ期合并者Ang-2阳性表达率（85．71％，36／42）高于0-Ⅰ期和Ⅱ期合并者（52．63％，20／38）（P＜0．05）。结论Ang-2与食管鳞癌的血管生成及其发展密切相关，可能通过促进食管鳞癌中的血管生成而促进其发展。
Objective To examine the expression of angiopoietin-2（Ang-2） in squamous carcinoma of esophagus, and discuss the relationship between Ang-2 and microvessel density（MVD） and clinical pathological features of squamous carcinoma of esophagus. Method The expression of Ang-2 and CD34 in 80 squamous carcinoma of esophagus and 25 normal esophagus were detected by immunohistochemistry SABC technique,and the MVD of tissues signed by CD34 was counted. Results The expression of Ang-2 in squamous carcinoma of esophagus was higher than that in normal esophagus （P 〈 0.05）.The expression of Ang-2 in the stage 0- Ⅰ and Ⅱ squamous carcinoma of esophagus was lower than that in stage Ⅲ and Ⅳ （P 〈 0.05 ）.The expression of Ang-2 in squamous carcinoma of esophagus was correlated with differentiation of esophageal carcinoma and lymph node metastasis and infiltrative deepness.There was a remarkable positive correlation between the expression of Ang-2 and MVD in squamous carcinoma of esophagus （r = 0.603, P 〈 0.05）. Conclusion The expression of Ang-2 may be related to the development of squamous carcinoma of esophagus,and may promote the development of squamous carcinoma of esophagus by promoting angiogenesis in tumor.
出处
《中国医师进修杂志（外科版）》
2009年第1期14-16,共3页
Chinese Journal of Postgraduates of Medicine
基金
基金项目：河南省卫生厅立项课题（200687）
