摘要
目的探讨家族史在原发性肝癌(primary hepatic carcinoma,PHC)遗传不稳定性中的作用。方法未经治疗前随机抽取PHC患者和PHC患者的一级亲属取外周血进行体内淋巴细胞微核试验,比较PHC自发微核和肝癌患者一级亲属及自然人群对照组的差异。结果PHC组、一级亲属组微核率(micronucleus frequent,MNF)分别与对照组相比,MNF差异有显著性(P<0.01);PHC组与一级亲属组自发MNF无显著差异(P>0.05);PHC患者中,有、无癌家族史两组的MNF差异有显著性(P<0.01)。结论家族史在PHC遗传不稳定演进中起促进作用,体内微核试验可作为PHC遗传不稳定性评价的生物学标志物。
Objective To investigate the effect of the family medical history in the genetic instability of primary hepatic carcinoma （ PHC）. Methods The mieronucleus （MN） test in peripheral blood lymphocytes was conducted in a group of patients randomly selected from in - hospital patients before therapy and their first degree relatives. Results The differences of the micronucleus frequency （MNF） between PHC patients ,first degree relatives and controls were statistically significant （P 〈 0.01 ）. There was no difference of MNF between PHC patients and their first degree relatives （P 〉 0.05 ）. A significant difference of MNF（ P 〈 0.01 ） was observed between patients with family history of cancer and those with no family history. Conclusion The family history of cancer would be a promoter in the genetic instability of PHC, and the MN formation will be a useful biomarker for evaluating the genetic instability of PHC.
出处
《医学研究杂志》
2009年第1期49-51,共3页
Journal of Medical Research
