摘要
目的:研究癌症患者初诊时和治疗前后的血红蛋白(Hb)变化、贫血发生情况及其与临床分期、年龄、消化道出血和化疗等方面的关系。方法:对我院近10年期间住院的3079例癌症癌患者进行回顾分析,研究治疗前后Hb值的变化和贫血的发生例数,并按临床分期、年龄、出血、性别和年龄分组进行分析。结果:1)3079例患者初诊时(治疗前)贫血发生率为45.0%(1386例),治疗后发生率为63.0%(1941例),P<0.001。Ⅰ级984例(50.7%),Ⅱ级615例(31.7%),Ⅲ级188例(9.7%),Ⅳ级154例(7.9%)。初诊时Hb值(110.3±22.9)g/L,治疗后为(104.8±23.8)g/L,P<0.001。2)单因素分析出血、临床分期、年龄、化疗和性别均是贫血的危险因素(均为P=0.000)。而Logistic多因素回归分析结果则为在P<0.05水平,出血、分期、年龄和化疗是贫血的危险因素(均为P=0.000),但性别则未能进入模型,P=0.777。3)胃癌、肺癌、肠癌、食管癌、淋巴瘤和泌尿生殖肿瘤的总贫血发生率均显著高于初诊时发生率,P<0.001;肺癌、淋巴瘤、食管癌、泌尿生殖肿瘤和头颈部癌治疗后的Hb值均明显低于初诊时,差异有统计学意义。4)各种类型肿瘤的贫血的发生率有所不同,但贫血程度的NCI分级则无统计学意义。结论:癌症患者有较高的贫血发生率;贫血的发生与临床分期、年龄、出血和化疗有密切关系,与患者性别无密切关系。高龄、出血、中晚期患者更易发生贫血。
OBJECTIVE： To explore the anemia incidence of patients with cancer, and analyse tbe correlation between anemia and age, clinical stage, hemohhrage of digestive tract and chemotherapy. METHODS： All 3 079 cancer patients were involved. Both the pre-therapy and post-therapy patient＇s hemoglobins（Hb） were examined and the results were analysed. RESULTS： 1）The anemia incidences of 3 079 patients were 45.0%（1 386 cases） and 63.0%（1 941 cases） respectively in pre therapy and post therapy, P〈0.001. For anemia grade, grade Ⅰ was 50.7% （984 cases）, grade Ⅱ 31.7%（615 cases）, grade Ⅲ 9.7%（188 cases）, and grade Ⅳ 7.9%（154 cases）. The Hb levels in pre-therapy and posttherapy were （110.3±22.9） g/L and （104.8±23.8） g/L respectively, P〈0.001. 2）Logistic regression results： the ane mia had closed correlation with hemohhrage, clinical staging, age and chemotherapy（P= 0. 000）, but had not correlation with sex, P= 0. 777. 3）The anemia incidences of gastric cancer, lung cancer, urogenital neoplasms colorectal cancer, esophageal cancer, and lymphoma were higher in post-therapy than those in pre-therapy, and the Hb levels of lung cancer, breast cancer, esophageal cancer, and lymphoma etc were lower in post therapy than those in pre-therapy, respectively, P〈0. 001. 4） The incidence of anemia in all those cancer patients was different according to the tumor variety, but NCI degree of the anemia was not different. CONCLUSION： The anemia incidence is high in patients with cancer, the anemia is closely correlated with hemohhrage, clinical staging, age, and therapy, but not correlated with sex.
出处
《中华肿瘤防治杂志》
CAS
2008年第20期1540-1543,共4页
Chinese Journal of Cancer Prevention and Treatment
