摘要
目的:探讨原发于肾脏的脂肪肉瘤的临床病理学特点、诊断、治疗、组织发生及预后。方法:4例均行B超、CT或MRI检查,进行病肾根治性切除术,其中1例术后失访,另1例术后未进行任何治疗。对4例肾脂肪肉瘤进行常规HE、组织化学及免疫组织化学染色观察。结果:未进行任何辅助治疗的患者于手术4个月复发。4例显微镜下表现、组织化学及免疫组织化学染色均显示脂肪源性肿瘤的特点。结论:肾原发性脂肪肉瘤少见,临床诊断较困难,依靠肾切除标本的病理检查,配以组织化学染色和免疫组织化学染色可确诊。复习文献,该肿瘤恶性度高,且位置深,一般发现已属晚期,故预后甚差。化疗、放疗效果均不理想,手术切除病肾是唯一可行方法,免疫治疗可以提高患者生存率。
Objective： To report 4 cases of liposarcoma of the kidney. The clinical features, diagnosis and therapeutic aspects, histogenesis as well as the prognostic factors of this tumor were reviewed. Methods： The clinical diagnosis was confirmed by ultrasonic examination, CT or MRI. All the patients underwent radical nephreetomy, one patient＇s follow up was lost, and the other 3 received chemotherapy or radiotherapy postoperatively ,4 specimens were stained with hematoxylin and eosin（ HE）,histochemical and immunohistocheInieal methods. Results： The patient without immu- notherapy experienced local metastasis 4 months after the operation. The features of HE, histoehemieal and immuno- histoehemical staining showed that the tumor was originated from fat tissue. Conclusion： Liposarcoma of the kidney is an uncommon malignant mesenchymal tumor. It is difficult to make the diagnosis for clinician. The tumor has its pathological features, so a definite diagnosis can be made with the pathological examination of the kidney. This tumor is high malignant with a poor prognosis. The treatment of choice is by radical nephrectomy. Immunotherapy can promote the prognosis.
出处
《现代肿瘤医学》
CAS
2009年第1期74-76,共3页
Journal of Modern Oncology
关键词
肾肿瘤
脂肪肉瘤
预后
kidney neoplasms
liposarcoma
prognosis
