摘要
目的探讨丹参注射液对体外循环(CPB)术后患者红细胞免疫功能的影响。方法63例CPB手术患者,分为丹参注射液组(31例)和对照组(32例);丹参注射液组从术前5 d至术中CPB结束时,成人每天静脉滴注50 g.L-1葡萄糖250 mL+丹参注射液20 mL,儿童每天丹参注射液1 mL.kg-1+50 g.L-1葡萄糖50 mL;对照组输注等量50 g.L-1葡萄糖。于麻醉前、转机前,术中转机30 min,停机5 min,术后24 h、72 h、7 d抽取静脉血检测2组患者红细胞C3b受体花环率(RBC-C3bRR)、红细胞免疫复合物花环率(RBC-ICR)。结果2组患者麻醉前、转机前RBC-C3bRR和RBC-ICR水平差异无统计学意义(P>0.05)。丹参注射液组患者RBC-C3bRR、RBC-ICR停机5 min、24 h、72 h及7 d明显高于对照组(P<0.05),并且在术后7 d已基本恢复到麻醉前水平,而对照组术后7 d仍低于麻醉前水平。结论CPB可以导致红细胞免疫功能低下,围术期应用丹参注射液能明显改善CPB患者术后红细胞的免疫功能,促进受损红细胞免疫功能的恢复。
Objective To explore the effect of injection salviae mihiorrhiza on erythrocyte immunity function in patients after cardiopulmonary bypass（CPB）. Methods Sixty-three patients who were underwent CPB were divided into salviae group （31 cases） and control group （32 cases）. Patients in the salvia group were treated with injection salviae mihiorrhiza 20 mL which was added into 50 g · L^-1 glucose 250 mL,the children were treated with injection salviae miltiorrhiza 1 mL· kg^-1 which was added into 50 g · L^-1 glucose 50 mL once a day. The patients in control group were given 50 g · L^-1 glucose with the same dose. Then venous blood of them was collected preanesthesia, prior to CPB ,30 min after CPB ,5 min after discontinuation of CPB and, 24 h,72 h and 7 d after CPB. The red blood cell C3b receptor rosette rate（RBC-C3bRR） and red blood cell immune complex rosette rate（RBC-ICR） were detected. Results There was no statistically significant in RBC-C3bRR and RBC-ICR preanesthesia and prior to CPB between two groups（ P 〉 0. 05 ）. In the salvia group, RBC-C3bRR and RBC-ICR were significantly higher at 5 min before discontinuation of CPB,24 h,72 h,and 7 d after operation than those in the control group respectively（ P 〈 0.05 ）. And they restored to the normal levels in the 7^th day after operation in salvia group, while they were still lower than those preanesthesia in control group. Conclusion Application of injection salviae mihiorrhiza in the peri-operative period can significantly improve the hypo-immunological function of erythrocyte which was damaged by CPB. And it may promote the recovery of erythrocyte immunity.
出处
《新乡医学院学报》
CAS
2009年第1期77-79,共3页
Journal of Xinxiang Medical University
关键词
丹参注射液
体外循环
红细胞免疫
injection salviae miltiorrhiza
cardiopulmonary bypass
erythrocyte immunity
