摘要
目的检测血浆中可溶性E-选择素(sE-Selectin)及肿瘤坏死因子-α(TNF-α)水平以研究其在重症肺炎患者的早期诊断及预后判断中的意义。方法以酶联免疫吸附法(ELISA)检测轻症肺炎患者30例和重症肺炎患者36例的血浆sE-selectin和TNF-α浓度。结果重症肺炎组血浆sE-selectin和TNF-α浓度明显高于轻症肺炎组(P均<0.05),发生MODS者的血浆sE-selectin和TNF-α水平高于未发生MODS者(P均<0.05)。结论sE-Selectin和TNF-α也许可作为疾病进展的指标,对其监测有助于评估重症肺炎的发病过程和治疗效果。
Objective It is to measure the plasma levels of sE selectin and TNF-α in patients with severe pneumonia and evaluate the significance of them in early diagnosis and prognosis of severe pneumonia. Methods The levels of sE selectin and TNF-α in plasma of 36 cases with severe pneumonia and 30 cases with mild pneumonia were measured by ELISA. Results The levels of sE - selectin and TNF-α in plasma were markedly higher in severe pneumonia cases than in mild pneumonia cases （ P 〈 0.05）. The levels of the two markers were both higher in MODS cases than without MODS cases （P 〈 0.05）. Conclusion The levels of sE-selectin and TNF-α may be a useful marker in evaluating the disease progression and monitoring the disease status and treatment outcome of severe pneumonia.
出处
《现代中西医结合杂志》
CAS
2009年第3期229-230,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
