摘要
目的探讨高血压性脑出血患者血浆及脑脊液白介素-11(Interleukin-11,IL-11)浓度与格拉斯哥昏迷评分(GCS)、血肿量、脑室积血及生存率的关系。方法采用ELISA法对43例高血压性脑出血患者血浆及脑脊液IL-11进行检测。结果43例中25例生存患者血浆或脑脊液IL-11均明显低于死亡患者(P<0.05)。血浆及脑脊液IL-11预测脑出血死亡均有中等价值。结论IL-11可作为高血压性脑出血后神经损伤程度的实验室评价指标,可早期预测脑出血的预后。
Objective To determine plasma and cerebral spinal fluid （CSF） levels ofIL-11 in patients with hyper- tensive intracerebral hemorrhage （HICH） and correlation between IL-11 GCS, volume of hematoma, intraventricular hemorrhage and survival. Methods Forty-three patients with HICH were included. Plasma and CSF samples were collected on admission. Concentrations of IL-11 were measured with ELISA. Results Plasma or CSF IL-11 levels in the survival group （15.8±11.0pg/mL or 100.8±83.5pg/mL） were significantly lower （P=0.021 or P=0.007）than those in the nonsurvival group（29.9±20.2pg/mL or 186.2±105. 1pg/mL）. Both CSF and plasma IL-11 had significant diagnostic values under ROC curve （P〈0.05）. Conclusion IL-11 is highly associated with mortality caused by HICH. It is our belief that IL- 11 can be an useful clinical marker for prognosis of HICH.
出处
《现代实用医学》
2008年第12期932-934,共3页
Modern Practical Medicine
基金
浙江省杭州市医药卫生科技计划项目
编号2006B005
关键词
白细胞介素11
高血压脑病
预后
Interleukin- 11
Intracerebral hemorrhage
Intraventricular hemorrhage
