摘要
目的研究血清脂蛋白(a)[Lp(a)]浓度与冠心病患者冠脉病变程度及心肌梗死发生的关系。方法选取行冠脉造影检查者384例作为研究对象,根据冠脉病变支数分为正常对照组、单支病变组、双支病变组、三支病变组,根据诊断分为正常对照组、心绞痛组、心肌梗死组,比较各组血清Lp(a)浓度。结果单支病变组、双支病变组、三支病变组的血清Lp(a)浓度均显著高于对照组(P<0.05,<0.01),但三组内比较差异没有统计学意义。心绞痛组、心肌梗死组血清Lp(a)浓度亦均显著高于对照组(P<0.01),心绞痛组和心肌梗死组相比差异亦有统计学意义(P<0.01)。Lp(a)与冠脉病变Gensini积分明显相关(偏相关系数r=0.143,P<0.01)。结论血清Lp (a)浓度与冠心病冠状动脉病变程度成正相关,且与心肌梗死的发生密切相关。
Objective To study the relationship between serum lipoprotein（a） [ Lp（a） ] level with severity of coronary artery stenosis and tile incidence of myocardial infarction. Methods Totally 384 patients who underwent coronary angiography were included. First, they were divided into four groups according to the number of coronary artery stenosis ： normal control group, single vessel disease group, double vessels disease group and three vessels disease group. Secondly, they were divided into three groups according to the diagnosis： normal control group, angina petoris group and myocardial infarction group. Then serum Lp（a） level was compared among different groups. Results Compared with normal control group, serum Lp（a） level was significantly higher in all the groups of patients with coronary artery disease. Among which, serum Lp（a） level was significantly higher in myocardial infarction group than angina pectoris group. No marked difference in serum Lp（a） level was found among groups of single vessel disease, double vessels disease and three vessels disease, but serum Lp（a） concentration was positively correlated with Gensini score of coronary stenosis （partial correlation coefficient （r = 0. 143 ,P 〈 0.01 ）. Conclusion Serum Lp （a） level is positively correlated with the degree of coronary artery stenosis and is also closely correlated with myocardial infarction.
出处
《山东医药》
CAS
北大核心
2008年第46期7-9,共3页
Shandong Medical Journal
关键词
冠状动脉疾病
心肌梗死
脂蛋白(a)
coronary artery disease
myocardial infarction
lipoprotein（a）
