摘要
目的探讨滥用酒精与抗氧化剂的关系。方法用分光光度比色分析法检测１９４例４０岁男性滥用酒精者和５０例４０岁男性无饮酒史健康者血浆维生素Ｃ（Ｐ－ＶＣ）、维生素Ｅ（Ｐ－ＶＥ）、β－胡萝卜素（Ｐ－β－ＣＡＲ）含量，在Ｃｏｍｐａｑ５８６／１６６微机上用ＳＰＳＳ／７．０和Ｓｔａｔｉｓｔｉｃａ／５．０统计软件包分析处理。结果滥用酒精组及各滥用酒精史组和各滥用酒精量组的Ｐ－ＶＣ、Ｐ－ＶＥ、Ｐ－β－ＣＡＲ平均含量均显著降低（Ｐ＜０．０５～０．０１），滥用酒精者的Ｐ－ＶＣ、Ｐ－ＶＥ、Ｐ－β－ＣＡＲ值均随滥用酒精史延长和滥用酒精量增加而逐渐降低（Ｐ＜０．０１）。结论滥用酒精者体内的氧化和抗氧化平衡严重失调，氧自由基反应病理性加剧。
Objective The study was designed to evaluate the relationship between alcohol abuse and antioxidants. Methods The plasma vitamin C (P VC), plasma vitamin E (P VE), plasma β carotene (P β CAR) concentrations were measured in 194 male alcohol abusers aged 40 years and compared with 50 male non drinkers aged 40 years by spectrophotometer. All statistical analyses were performed with SPSS/7.0 and statistica/5.0 on computer. Results The average P VC, P VE, P β CAR levels in alcohol abuser group, different groups of abusing alcohol time and different groups of abusing alcohol quantity were lower than those of the non drinker group( P <0.05～0.01). The average P VC, P VE, P β CAR levels in abuser group decreased with the increased time and amount of alcohol abuse ( P <0.0001). Conclusion The balance between oxidation and antioxidation in the bodies of the alcohol abusers was serious imbalance, oxygen free radical reaction was pathological exacerbated.
出处
《中华精神科杂志》
CAS
CSCD
1998年第1期34-36,共3页
Chinese Journal of Psychiatry
