摘要
重症急性胰腺炎（SAP）是临床常见的急腹症，病情凶险，病死率高。肠源性感染是SAP病情加剧、病死率增加的重要原因。肠道免疫屏障是肠黏膜屏障的重要组成部分，肠道黏膜免疫构成机体防止肠道感染的第一道防线。SAP早期常发生肠道免疫功能损伤，使肠道的免疫防御功能受到抑制，对病原体的免疫应答减弱。因此肠道免疫功能损伤与SAP的肠源性感染密切相关。本文就SAP肠道免疫功能的损伤及其可能机制简要综述。
Severe acute pancreatitis （SAP） is the common clinical acute abdomen. Its pathogenetic condition is severe,and case fatality is high. Enterogenic infection is an important factor aggravating the condition of SAP and matality. Intestinal Immunologic barrier is an important component of intestinal mucous membrane barrier,and mucosal immunity is the first line defensing intestinal infection. Intestinal immune function often was impaired in the early stage of SAP,which will inhibit the defensive immune function of intestinal and decrease the immune response to pathogen. So, impaired intestinal immune function is closely related to enterogenic infection of SAP. This article reviews the injury of intestinal immune function of SAP and its possible mechanism.
出处
《医学综述》
2009年第1期104-107,共4页
Medical Recapitulate
关键词
急性胰腺炎
肠道免疫屏障
损伤
Acute pancreatitis
Intestinal immune barrier
Injury
