摘要
对７０年代和８０年代初测定血清胆固醇等４８１４名１８岁以上（平均４５．２岁）北京某钢厂工人平均随访１４．５年，发生癌症１２７例。癌症组胆固醇水平为１７８．４ｍｇ／ｄｌ，低于非癌症组胆固醇１８７．１ｍｇ／ｄｌ，差异有统计学意义。将基线人群按胆固醇的百分数的四分位数法分成四组后，单因素卡方分析，最低胆固醇组的肺癌、消化系统癌及全肿瘤死亡率分别是最高胆固醇组的４．４９倍、３．３２倍、１．４８倍，统计学检验除全肿瘤外，均有显著意义；在剔除血清胆固醇测定三年内死亡的１０名癌症病人后，肺癌（Ｐ＜０．０１）、消化系统癌（Ｐ＜０．０５）及全肿瘤（Ｐ＜０．０５）在统计学上均有显著性意义。对上述各类癌症分别经Ｌｏｇｉｓｔｉｃ多因素回归分析，并控制年龄、吸烟、饮酒的影响后，肺癌、消化系统癌及全肿瘤均与胆固醇有负相关，最低胆固醇组癌症死亡率分别是最高胆固醇组的２．３４倍、２．７３倍、１．４４倍；剔除血清胆固醇测定三年内死亡的１０名肿瘤病人后，再经非条件Ｌｏｇｉｓｔｉｃ分析，肺癌、消化系统癌及全肿瘤仍与胆固醇存在负相关，统计学检验仍均有显著意义。
4 814 men workers aged above 18 years (average 45.2 years)were initially examined in 1974,1979,1980 and followed up a median of 14.5 years.127 cases of all tumors have occurred.The mean cholesterol level of cancer workers (1784mg/dl) was lower than that of non-cancer workers (1871mg/dl) with significant association.Subjects were divided into 4 groups according to quartile of serum cholesterol level at basic measurement.When 10 cases occurring cancer within 3 years of serum cholesterol determination were dismissed,the relative risk(RR) of all tumors,lung cancer,gastrointestinal cancer in the lowest cholesterol quartile was 158(P<005),448(P<001) and 498(P<005) times respectively more than the relative risk of that in the highest quartile for mortality with a single factor analysis.Using multiple logistical regression,these inverse associations were statistically significant after adjustment for age,cigarette smoking and alochol.The mortality of all tumors,lung cancer,gastrointestinal cancer in the lowest cholesterol quartile was 2.34,2.73,1.44 times than that in the highest quartile separately;the inverse associations were not changed after 10 cases occurring cancer within 3 years of cholesterol determination were dismissed.
出处
《中国慢性病预防与控制》
CAS
1998年第1期8-10,共3页
Chinese Journal of Prevention and Control of Chronic Diseases
