摘要
目的：观察石斛夜光颗粒剂对大鼠实验性白内障的形成和家兔球结膜微循环的影响。方法：将１２０只大鼠随机分为对照组，模型组和丸药组，其中丸药组又分为大剂量组，中剂量组和小剂量组。分别记录实验开始后第１０天、第１５天和第２０天晶状体的混浊程度。将３２只家兔随机分为对照组、大剂量组、小剂量组和丸药组。灌胃给药６０ｍｉｎ后经耳静脉注射１０％高分子右旋糖酐６ｍｌ／ｋｇ，观察球结膜血管的改变。结果：大鼠实验性白内障的发生率在模型组、丸药组和大、中剂量组中分别为３３３％～６６７％、３６４％～６３６％和２７３％～７２７％，组间比较有显著差异（Ｐ＜００５）；在大中小剂量组中分别为２７３％～７２７％、３３３％～６６７％和４１７％～５８３％。家兔球结膜微循环观察显示在血液颜色、血流形态、血管口径、毛细血管交叉点数方面，各组间均有显著差异（Ｐ＜００５）。结论：石斛夜光颗粒剂具有延缓大鼠实验性白内障形成和改善家兔球结膜微循环的作用。
OBJECTIVE: To study effect of shihu yeguanggranule in the formation of experimental cataracts of rats and the conjunctive microcirculation of the rabbits METHODS: one hundred and twenty rats were random divided into control group, model group, and pill group The rats of pill group were divided to high dose group, middle dose and small dose group once more The changing degree of lens opacity of rats was observed respectively at tenth day, fifteenth day, and twentieth day after the experiment Thirty two rabbits were random divided into control group, high dose group, middle dose group, and pill group The rabbits were taken the drugs orally, after 60 minute 10% macromolecular dextran 6 ml/kg were injected venously in each groups The change of conjunctive microcirculation was observed respectively RESULTS: Developed ratio of experimental cataracts of the rats in the model group, pill group and high and middle dose group was 333%～667, 364%～636% and 273%～727%, there was statistic significant between the groups (P<005) The developed ratio was 273%～727%, 333%～667% and 417%～583% in the high dose group , middle dose group, and small dose group respectively There was statistic significant between the high dose groups, middle dose group and small dose group in conjunctive microcirculation the color and moving situation of blood, vascular bore and the number of crossing points (P<005) CONCLUSIONS: Shihu yeguang granule can delay the formation of experimental cataract of rats and improved the conjunctive microcirculation of the rabbits
出处
《中国中医眼科杂志》
1998年第1期3-6,共4页
China Journal of Chinese Ophthalmology
