摘要
Bounous等采用向肠腔内注射胰蛋白酶抑制剂,或预先结扎胰管,能减轻因为出血性休克所引起的肠黏膜损伤,表明胰蛋白酶在肠黏膜的损伤中起着重要的作用。肠梗阻时,常常伴有不同程度的肠黏膜病变。我们设想用奥曲肽抑制蛋白酶的分泌,减少消化液的分泌,减轻肠梗阻时肠黏膜的损伤。
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2009年第1期125-125,共1页
Chinese Journal of Experimental Surgery
参考文献11
-
1Bounous G, Hampson LG, Gurd FN. Cellular nucleotieds in hemorrhagic shock. Relationship of intestinal metabolic changes to hemorrhagic enteritis and burrier function of the intestinal mucosa. Ann Surg, 1964,160:650-666. 被引量:1
-
2Bounous G, Brown RA, Molder DS, et al. Ablation of tryptic enteritis in shocked dog. Arch Surg, 1965,91:371-375. 被引量:1
-
3Deitch EA, Bridges WM, MA JW, et al. Obstructed intestine as a reservoir for systemic infection. Am J Surg, 1990, 159: 394-401. 被引量:1
-
4Yamaner S, Bugra D, Muslumanoglu M, et al. Effects of octreotide in healing of intestinal anastomosis following small bowel obstruction on rats. Dis Colon Rectum, 1995,38:308-312. 被引量:1
-
5Aldemir M, Kokoglu OF, Geyik MF, et al. Effects of octreotide acetate and Saccharomyces boulardii on bacterial translocation in an experimental intestinal loop obstruction model of rats. Tohoku J Exp Med, 2002,198 : 1-9. 被引量:1
-
6Walsh KA. Trypsinogens and trypsins of various species. Methods Enzymol, 1970, 19:41-43. 被引量:1
-
7Chiu CJ,McArdle AH,Brown R,et al. Intestinal mucosal lesion in low-flow states. Arch Surg, 1970,101:478-483. 被引量:1
-
8Shields R. The absorption and secretion of fluid and electrolytes by the obstructed bowel. Br J Surg, 1965,52:774-779. 被引量:1
-
9Wright HK, O' Brien NN, Tilson MD. Water absorption in experimental closed segment obstruction of the ileum in man. Am J Surg,1971,121:96-99. 被引量:1
-
10Mystakidou K, Tsilika E, Kalaidopoulou O, et al. Comparison of octreotide administration vs conservative treatment in the management of inoperable bowel obstruction in patients with far advanced cancer:a randomized, double-blind, controlled clinical trial. Anticancer Res, 2002,22 : 1187- 1192. 被引量:1
同被引文献57
-
1李幼生,黎介寿.再论术后早期炎性肠梗阻[J].中国实用外科杂志,2006,26(1):38-39. 被引量:542
-
2Gotzsche PC, Hrobjartsson A. Somatostatin analogues for acute bleeding oesophageal varices [ J ]. Cochrane Database Syst Rev, 2008, 16 (3) : CD000193. 被引量:1
-
3Kutun S, Ulucanlar H, Celik A,et al. Effects of octreotide on healing of mechanical ileus in rats[J]. Saudi Med J,2008,29(4) :539 -543. 被引量:1
-
4Aldemir M, Kokoglu OF, Geyik MF, et al. Effects of octreotide acetate and Saccharomyces boulardii on bacterial translocation in an experimental intestinal loop obstruction model of rats [ J ]. Tohoku J Exp Med,2002,198( 1 ) :1 -9. 被引量:1
-
5Gong AY, Tietz PS, Muff MA, et al. Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes [ J ]. Am J Cell Physio1,2003,25 (6) :284. 被引量:1
-
6Jimenez - Garcia A, Balongo - Garcia R, Alconero FF, et al. Intestinal wall damage in simple ileus in rabbits: immune - modulator role of somatostatin [ J ]. Hepatogastroenterology,2004,51 ( 58 ) : 1030 - 1036. 被引量:1
-
7Shima Y, Yamaguchi K, Miyata Y, et al. A clinical study using octreotide in relieving gastrointestinal symptoms due to bowel obstruction in a terminally ill cancer patient [ J ]. Gan To Kagaku Ryoho, 2004,31 (9) :1377 - 1382,. 被引量:1
-
8Shima Y, Ohtsu A, Shlrao K, et al. Clinical efficacy and safety of octreotide ( SMS201 - 995 ) in terminally ill Japanese cancer patients with malignant bowel obstruction[ J ]. Jpn J Clin Oncol,2008,38 (5) : 354 -359. 被引量:1
-
9贾忠,贺冠海,封光华,方欣.成人肠梗阻诊治进展[J].医学研究杂志,2007,36(9):13-17. 被引量:9
-
10李健,金懋林,沈琳.醋酸奥曲肽在恶性肿瘤肠梗阻中的应用[J].中华胃肠外科杂志,2007,10(5):479-481. 被引量:14
引证文献8
-
1刘汉东,李晓娇.奥曲肽治疗肠梗阻疗效的Meta分析[J].现代临床医学,2011,37(2):110-112. 被引量:3
-
2彭铭,谢纲,张军.奥曲肽治疗肠梗阻患者38例临床效果观察[J].中国医药指南,2012,10(27):549-550. 被引量:2
-
3方征,高登辉,王恒毅.奥曲肽治疗急性肠梗阻临床疗效分析[J].安徽卫生职业技术学院学报,2012,11(6):16-17.
-
4章晓萍,孙世民,李皖生.奥曲肽联合乌司他丁治疗术后早期炎性肠梗阻疗效观察[J].放射免疫学杂志,2013,26(2):252-254. 被引量:7
-
5郭玉香.132例急性肠梗阻患者临床治疗效果观察[J].中外医疗,2013,32(28):119-119. 被引量:4
-
6饶玉文,徐是,李长鹏.丙氨酰-谷氨酰胺双肽联合奥曲肽用于肠梗阻术后疗效观察[J].基层医学论坛,2013,17(28):3806-3807. 被引量:1
-
7裴平.奥曲肽对粘连性肠梗阻患者肠黏膜屏障功能影响及疗效观察[J].中国药师,2014,17(7):1172-1174. 被引量:19
-
8任伟耀,陈德明,范海鹰,梁健雄,王国庆,李正贤.奥曲肽对术后早期炎症性肠梗阻治疗效果评价[J].中国现代药物应用,2015,9(12):114-115. 被引量:2
二级引证文献37
-
1冯卓林.奥曲肽治疗肠梗阻的疗效观察[J].医学信息(医学与计算机应用),2014,0(24):188-189.
-
2Jun-Yi Jia.Protective effect of perioperative recombinant human growth hormone application on intestinal mucosal barrier function in patients with intestinal obstruction and the assessment of immune inflammatory response[J].Journal of Hainan Medical University,2017,23(11):71-74. 被引量:2
-
3罗应超,陈国强,张金强.生长抑素治疗结肠癌术后早期炎性肠梗阻的疗效分析[J].消化肿瘤杂志(电子版),2013,5(2):100-103. 被引量:5
-
4曾杰辉.奥曲肽治疗肠梗阻合并酸中毒的临床疗效观察[J].中国医学创新,2013,10(12):111-112. 被引量:1
-
5滕浩鹏.乌司他丁治疗炎性肠梗阻疗效观察[J].中国实用医刊,2014,41(16):81-82. 被引量:1
-
6江展庆.对急性肠梗阻患者开展急诊手术的临床分析[J].中外医疗,2014,33(16):94-95. 被引量:6
-
7闻久辉,罗世云,夏中平,黄宏斌,陈建丰.奥曲肽对术后早期炎性肠梗阻患者血清内毒素和超敏C反应蛋白水平的影响[J].中国现代医生,2015,53(12):84-86. 被引量:7
-
8张和平.保守治疗急性上消化道穿孔65例临床总结[J].中国伤残医学,2015,23(11):64-65. 被引量:2
-
9颜伟.奥曲肽治疗肠梗阻的有效性及安全性研究[J].中国临床研究,2015,28(8):1046-1047. 被引量:5
-
10许靓,池圣亮.生长抑素治疗急性粘连性肠梗阻的疗效及对肠黏膜屏障功能的保护作用[J].中国现代医生,2015,53(15):57-59. 被引量:12
-
1Infliximab作为克罗恩病的一线治疗方法是否为时尚早?[J].胃肠病学,2003,8(4):256-256.
-
2沈雁波,唐建中,黄中伟,庄燕,蔡丹磊.乌司他丁对重症肺炎患者炎性细胞因子变化的影响[J].中国交通医学杂志,2005,19(6):604-605.
-
3叶玲军,章渭方.乌司他丁对心内直视手术患者促炎性细胞因子的影响[J].实用医学杂志,2006,22(4):404-405. 被引量:2
-
4张树生.奥曲肽联用乌司他丁对SAP患者IL-6水平的影响及临床疗效观察[J].医学临床研究,2008,25(6):997-999. 被引量:5
-
5张美云.中药灌肠配合西医治疗急性胰腺炎33例临床观察[J].河北中医,2010,32(4):554-555. 被引量:2
-
6卢才教,张鹏,杨宁,徐建军,林才.泮托拉唑治疗严重烧伤患者消化道出血16例[J].中国基层医药,2006,13(2):335-335.
-
7付笑飞,刘东雷,王建军.乌司他丁对食管癌根治术患者肺损伤的保护作用及机制[J].山东医药,2010,50(27):58-59. 被引量:2
-
8付笑飞,赵松,刘东雷,王建军.氯胺酮对食管癌根治术患者的肺保护作用[J].中国老年学杂志,2010,30(13):1807-1808. 被引量:1
-
9曹得胜.乌司他丁治疗急性胰腺炎96例[J].陕西医学杂志,2010,39(6):751-752. 被引量:4
-
10李维东.乌司他丁对小儿体外循环手术中炎性反应和肾功能的影响[J].医学临床研究,2009,26(6):1014-1016. 被引量:2