摘要
牛膝散对注射佐剂引起的大鼠足跖肿胀有显著抑制作用，减少炎性渗出物中ＰＧＥ２的含量，说明能抑制炎性组织中ＰＧＥ２的生物合成。实验还表明，本品能显著升高血浆及血红细胞ＳＯＤ活力，减少脂质过氧化产物—ＭＤＡ含量，表明其有一定清除自由基的作用。本品对抗炎症因子和清除自由基的作用，可能是其抗炎、祛风湿的重要机理之一。
Achyranthes root (Radix Achyranthis Bidentatae) could significantly reduce the swelling induced by the injection of adjuvant in the paw of rats and reduce the content of PGE2 in the inflammatory exudate,which suggest that it could inhibit the biosynthesis of PGE2 in the inflammatory tissues.It could also activate the SOD of plasma and erythrocytes and decrease the contents of MDA,the product of lipid peroxidation,which suggest that ti could scavenge free radical to some extent.Its effects of counteracting inflammatory factor and scavenging free radical might be a very important mechanism through which it counteracts inflammation and deals with rheumatic and rheumatoid arthritis.
出处
《南京中医药大学学报》
CAS
CSCD
1998年第1期26-27,共2页
Journal of Nanjing University of Traditional Chinese Medicine
关键词
牛膝散
炎症因子
自由基
achyranthes root,inflammatory factor,free radical
