摘要
为探讨铝的毒作用机制．本研究选择某铝厂铝作业工人72名作为研究对象，以同一地区非铝作业工人41名作为对照人群，观察铝对职业人群红细胞膜Na-K－ATP酶活性的影响。结果显示，各年龄段铝作业工人的尿铝含量均明显高于对照组；丙二醛（MDA）含量无显著性差异；Na－K－ATP酶活性铝接触组与对照组之间有明显差异，以35～44岁年龄段铝作业工人为最高，并与同年龄段对照工人存在显著性差异。长期职业性铝接触可以引起红细胞膜Na－K－ATP酶活性升高，这一结果可能是由于铝的直接作用，而与机体脂质过氧化作用无关．
To explore the mechanism of aluminum (Al) toxicity, 72 Al-exposed workers and 41 unexposed workers as controls were investigated to observe the effect of Al on Na-K-ATPase activity of erythrocyte membrane. Results showed that urine Al levels of Al-exposed workers were markedly higher than those of the unexposed workers in all age groups. Na-K-ATPase activity between exposed and unexposed workers was markedly different. ATPase activity of 35-44 group in Al-exposed workers was the highest, it differed distinctively from that of the same age group in unexposed workers. However. the content of malonaldehyde (MDA) in serum showed no difference between both groups. It suggests that long-term occupational exposure to Al might have a direct effect on Na-K-ATPase activity of erythrocyte membrane, this might have nothing to do with lipid peroxidation.
出处
《工业卫生与职业病》
CAS
CSCD
1998年第1期6-8,共3页
Industrial Health and Occupational Diseases
