摘要
Objective To investigate the correlation of CK5/6 and CK17 expression with clinical outcome in patients with triple-negative[ ER（-）, PR（-）, Her-2 （-） ] breast cancer. Methods 112 patients with breast cancer treated by surgery between 2000 and 2002 were included in this study. All cases were immunohistochemically proven to tripe-negative. Samples of formalin-fixed and paraffin-embedded surgical specimeans were obtained for immunohistological examination for CK5/6 and CK17 expression. The correlation of the gene expression with clinicopathological features and outcome of the patients was analyzed. Results Of the 112 tripe-negative patients, five-year disease-free survival rate was 73.2 % （82/112）. The positive rate of both CK5/6 and CK17 was 21.4 % （24/112）, either CK5/6 or CK17 postitive was 46.4% （52/112）.
