摘要
应用酶联免疫吸附法（ＥＬＩＳＡ），测定了６８例Ｇｒａｖｅｓ病（ＧＤ）患者和２０例健康对照者血清白细胞介素－６（ＩＬ－６）含量。结果表明：①ＧＤ患者未治疗组、部分缓解组和缓解组血清ＩＬ－６水平分别高于健康对照组（２８３２．８７±１２６６．４４、２３６１．３９±１１５３．７２、１５８４．５１±１２７３．３１比１３．５６±６．２７ｐｇ／ｍｌ，Ｐ＜０．０１）；②血清游离Ｔ３（ＦＴ３）、游离Ｔ４（ＦＴ４）与ＩＬ－６呈正相关关系（ｒ＝０．２５９～０．２７８，Ｐ＜０．０５）。推测血清ＩＬ－６水平异常是ＧＤ的免疫发病机制之一。
Serum levels of interleukin6(IL6)in 68 cases of Graves disease(GD) patients and 20 cases of healthy subjects were measured with a ELISA method The results showed that① Serum IL6 levels of GD untreated group,GD partialremission group and GD remission group were much higher than those of healthy controls(283287±126644,236139±115372,158451±127331 vs 1356±627pg/ml,P<001);②Serum free T3, free T4 levels had much positive correlation with serum IL6 (r=0259～0278,P<005)This study may provide cluses to the immunopathogenesis in Graves disease
出处
《免疫学杂志》
CAS
CSCD
北大核心
1998年第1期40-41,共2页
Immunological Journal
基金
南京军区卫生部重点科研基金
