摘要
目的介绍环氧化物水解酶及其抑制物的理化性质及其在抗高血压治疗中的作用和机制。方法查阅相关文献,总结归纳环氧化物水解酶及其抑制物的理化性质和作用机制。结果可溶性环氧化物水解酶(sEH)广泛存在于哺乳动物组织中,是内源性抗高血压物质——二十碳脂酸(EET)的主要转换酶,破坏sEH基因或抑制sEH可引起血压下降。结论sEH抑制剂可能成为抗高血压的新药。
OBJECTIVE To introduce the effects of epoxide hydrolase and its inhibitions for the antihypertensive therapy. METHODS Consulting relative references, something about the role of epoxide hydrolase in hypertension control and its mechanisms was summarized. RESULTS Soluble epoxide hydrolase （sEH） is widely distributed in mammalian tissues. It is the primary enzyme that is responsible for the conversion of epoxyeicosatrienoic acids （EETs） which are endogenous antihypertensive eicosanoids. Disruption of the sEH gene or inhibition of sEH decreases blood pressure. CONCLUSION Potent selective sEH inhibitors have potentiahty to become a novel class of antihypertensive agent.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2008年第6期506-508,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
环氧化物水解酶
二十碳脂酸
抗高血压药物
epoxide hydrolase
epoxyeicosatrienoic acids
antihypertensive agent
