摘要
目的研究自发性脑出血患者血清基质金属蛋白酶-9(MMP-9)及其抑制因子基质金属蛋白酶抑制因子-1(TIMP-1)的含量及临床意义。方法采用酶联免疫吸附法对62例48小时内入院的脑出血患者血清MMP-9和TIMP-1水平进行测定,与正常对照组进行比较,同时用免疫比浊法测高敏C-反应蛋白(hs-CRP)水平,并与CT所示血肿周围水肿体积和神经功能评分进行相关分析。结果脑出血患者血清MMP-9及TIMP-1水平较正常对照组明显升高(P<0.01),脑出血组MMP-9的含量与CT所示出血灶周围水肿区体积呈显著正相关(r=0.627,P<0.01)。结论脑出血患者血清MMP-9及TIMP-1水平明显增高,血清MMP-9可能成为早期反映脑出血患者血肿周围水肿严重程度和预后的指标。
Objective To observe serum MMP-9 and TIMP-1 levels in patients with spontaneous intracerebral hemorrhage （ICH） and explore its clinical significance. Methods Serum MMP-9 and TIMP-1 were determined by enzyme-linked immunosorbent assay （ELISA） in 62 ICH patients hospitalized within 48h and 68 healthy people（control）. C-reactive protein was determined by immunoturbidimetry. The relationship between serum MMP-9 and the perihematomal edema（PIIE） volume measured by cranial CT scan and neurological assessment was investigated. Results Serum levels of MMP-9 and TIMP-1 were higher in ICH patients than those in healthy people （ P 〈 0.01 ）. Serum MMP-9 level was positively correlated with perihematomal edema volume（r = 0.627, P 〈 0.01 ）. Conclusions The levels of MMP-9 and TIMP-1 increased significantly in patients with ICH, it could be an earlier important factor to judge the severity of PHE and evaluate the prognosis.
出处
《心脑血管病防治》
2008年第6期367-369,共3页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
基金
浙江省台州市市级科研基金(072KY67)
关键词
脑出血
基质金属蛋白酶-9
组织抑制因子-1
脑水肿
Intracerebral hemorrhage
Matrix Metalloproteinase-9
Tissue inhibitor-1
Perihematomal
