摘要
目的:研究Wistar大鼠单次灌服辛伐他汀后体内药代动力学的性别差异。方法:利用高效液相色谱方法检测大鼠血浆中辛伐他汀浓度,采用非房室模型法计算各自药动学参数。结果:雌、雄大鼠体内Cmax分别为(144.66±22.31)ng·mL^(-1)和(165.91±52.50)ng·mL^(-1);t_(1/2)分别为(4.74±1.19)h和(14.98±6.64)h;AUC_(0-10)分别为(0.990±0.19)μg.h·mL^(-1)和(0.726±0.15)μg·h·mL^(-1);AUC0-∞分别为(1.62±0.47)μg·h·mL^(-1)和(2.19±0.62)μg·h·mL^(-1);MRT分别为(9.69±1.60)h和(23.08±8.89)h,经t-检验,雌、雄大鼠主要药动学参数t_(1/2)、AUC_(0-10)、MRT均有统计学显著性差异(p<0.01)。结论:辛伐他汀在大鼠体内的药代动力学存在明显的性别差异,辛伐他汀在雌性大鼠体内代谢较快。
Objective： To investigate the pharmacokinetic difference of simvastatin after oral single dose in female and male rats. Methods： The simvastatin concentration in plasma was determined by HPLC. Pharmacokinetic parameters were calculated by using non-compartment model. Results： The Cmax, t1/2, AUC0-10, AUC0-∞ and MRT of simvastatin in female and male rats were： （144.66± 22.31） ng·mL^-1, （4.74± 1.19） h, （0.990± 0.19）μg.h·mL^-1, （1.62±0.47） μg.h·mL^-1, （9.69± 1.60） h and （165.91±52.50） ng.mL^-1, （14.98±6.64） h, （0.726± 0.15） μg.h·mL^-1, （2.19± 0.62） μg.h·mL^-1, （23.08± 8.89） h respectively. In t-test, the pharmacokinetics had obvious difference between male rats and female rats. Conclusion： There were obvious sex differences of pharmacokinetics of simvastatin in rats. Simvastatin was eliminated faster in female rats.
出处
《现代生物医学进展》
CAS
2008年第12期2211-2213,共3页
Progress in Modern Biomedicine
基金
国家高技术研究发展(863)计划项目(2006AA090401)
