摘要
目的比较补肾壮骨冲剂、密盖息治疗绝经后骨质疏松成本-效果,进行经济学评价,为临床提供有效、实用治疗方案。方法将178例患者随机分为2组,补肾壮骨冲剂组88例,失访8例;密盖息组90例,失访4例。补肾壮骨冲剂组给予口服补肾壮骨冲剂;密盖息组给予密盖息肌肉注射治疗。观察治疗第2、4周两组的疼痛强度缓解情况、镇痛有效率,运用药物经济学方法进行成本-效果分析。结果①补肾壮骨冲剂组、密盖息组治疗绝经后妇女骨质疏松后第2周的疼痛强度分别为4.7365±1.6895和3.9535±1.3187,两组比较(P>0.05),总有效率分别为42.5%和53.49%(P>0.05);治疗后第4周的疼痛强度分别为2.2375±1.3430和1.9047±0.9239,两组比较(P>0.05),总有效率分别为92.5%和95.3%(P>0.05);②成本-效果比:治疗后第2周疼痛强度缓解的成本-效果比分别为75.47和398.05,有效率的成本-效果比分别为5.9953和30.2860;治疗后第4周疼痛强度缓解的成本-效果比分别为86.74和382.44,有效率分的成本-效果比别为5.5092和24.554;③敏感度分析:治疗后第2周疼痛强度缓解敏感度分析分别为67.93和358.25,有效率敏感度分析分别为5.3958和27.2574;治疗后第4周疼痛强度缓解敏感度分析分别为78.0664和344.20,有效率敏感度分析分别为4.9583和22.10。结论补肾壮骨冲剂可明显缓解绝经后妇女骨质疏松患者的疼痛,其疗效与密盖息相仿;但补肾壮骨冲剂有更好的成本-效果比。因此,补肾壮骨冲剂能比密盖息以更少治疗成本获得更大的效益。
Objective To compare the cost-effectiveness analysis （CEA） for treatment of postmenopausal osteoporosis pain by Bushen Zhuanggn granul（BZG） and calcitonin and to discover more effective and practical medicine to treat postmenopausal osteoporosis.Methods Totally 178 outpatients were randomly divided into BZG group（ n = 88, treated with Bushen Zhuanggu granules） and ealcitonin group （n = 90, treated with calcitonin）. Record the pain intensity and the efficiency rate of analgesia after 2 and 4 weeks, and then analyses the costeffectiveness of the two medicines by medical economical study. Results （1） The pain intensity of osteoprosis in BZG and calcitonin group after 2 weeks was 2.2375 ± 1.3430 and 1.9047± 0.9239 with no significant difference （ P 〉 0.05 ）. And the total efficiency was 42.5 % and 53.49 % with no significant difference （ P 〉 0.05 ）. The pain intensity of osteoprosis in the two groups after 4 weeks was 2. 2375 ± 1. 3430 and 1. 9047 ± 0. 9239 with no significant difference （ P 〉 0.05 ）. And the total efficiency of the two groups was 92.5 % and 95.3 % with no significant difference（ P 〉 0.05）. （2）CEA： Release degree of pain in the two groups after 2 weeks was 75.47 and 398.05, and total efficiency was 5. 9953 and 30.2860. Release degree of pain in the two groups after 4 weeks was 86.74 and 382.44, and total efiqciency was 5. 5092 and 24.554. （3）Sensitiveness analysis： Release degree of pain in the two groups after 2 weeks was 67.93 and 358.25, and total efficiency was 5.3958 and 27.2574. Release degree of pain in the two groups after 4 weeks was 78.0664 and 344.20, and total efficiency was 4.9583 and 22.10. Conclusion There is similar therapeutic effectiveness of BZG in the treatment of postmenopausal osteoporosis pain compared with calcitonin; however, BZG has lower CEA than calcitonin. Thus BZG can cost less medical resources and gain more effectiveness and utility.
出处
《中国骨质疏松杂志》
CAS
CSCD
2008年第12期896-899,共4页
Chinese Journal of Osteoporosis
基金
广东省科技计划项目(2005B40301005)
广东省中医药管理局科研课题(97318)
