摘要
目的通过建立猪附红细胞体感染的小鼠模型,对附红细胞体在小鼠模型中的感染进行病理变化的检测,以探索该病在啮齿类动物体内的发生、发展及转归的规律,揭示附红细胞体的致病机理。方法用感染了附红细胞体的猪血液感染昆明小鼠,定期进行感染率和病理组织学检测。结果建立了附红细胞体感染的小鼠模型,通过对感染小鼠模型的检测,发现在感染的不同阶段各组织器官均发生了不同的病理变化。结论成功建立了附红细胞体感染小鼠模型,通过对感染小鼠的感染率和病理组织学的观察和检测,进一步揭示了附红细胞体的致病机理。
Objective To establish a Mycoplasm suis Kunming mouse model with blood from the Mycoplasm suis infected pigs to explore the laws, the occurrence and development and outcome, of this disease in rodents to reveal the pathogenic mechanism of Mycoplasma suis further. Methods The Kunming mouses were inoculated with blood from the Mycoplasm suis infected pigs, the rate of infection and histopathological changes were determined in different stages after challenge. Results The Kunming mouse model was established successfully and the tissues and organs of different infection stages were detected. It was demonstrated that different pathological changes were in different infection stages. Conclusion Investigating the rate of infection and histopathological changes of the Kunming mouse model is beneficial to reveal Mycoplasma suis pathogenic mechanism.
出处
《实验动物与比较医学》
CAS
2008年第6期372-376,382,共6页
Laboratory Animal and Comparative Medicine
基金
辽宁省科技基金(2004408003)
