摘要
目的探讨正己烷接触工人的早期生物标志物。方法分别检测正己烷接触工人63名及对照组50名工人的尿2,5-己二酮、血清神经元特异烯醇化酶(NSE)及髓鞘碱性蛋白(MBP)水平。结果接触组工人尿2,5-己二酮含量为0.31～10.38mg/gCr,对照组未检出;接触组血清NSE和MBP含量分别为(9.02±3.87)μg/L和(1.47±0.41)μg/L,均显著高于对照组(P<0.05)。结论正己烷接触可导致血清NSE及MBP水平的升高,尿2,5-己二酮、血清NSE和MBP水平可作为正己烷接触的早期生物标志物。
Objective To study the biomarkers of workers exposed to n-hexane. Method 63 workers with exposure to n-hexane were selected as the exposed group, and 50 workers without exposure to any toxicants were chosen as the control group. The concentration of 2,5-Hexanedione in urine, neuron-specific enolase （NSE） and serum melin basic protein（MBP） were determined by ELISA. Result The concentration of 2,5-hexanedione in urine of exposed group was ranged from 0.31 to 10.38 mg/gCr, and it could not be detected in the control group. The levels of NSE and MBP in serum of exposed group were （9.02±3.87） and （1.47±0.41）ug/L, respectively, and were both higher than those in the controls （P〈0.05）. Conclusion Exposed to n-hexane could induce the increase of NSE and MBP in serum. 2,5-hexanedione in urine, NSE and MBP in serum can be used as the early biomarkers of workers exposed to n-hexane.
出处
《热带医学杂志》
CAS
2008年第12期1228-1229,1216,共3页
Journal of Tropical Medicine
基金
广东省医学科学研究基金(No.B2005017)
