摘要
目的制备载银等离子喷涂的硅灰石涂层,以期获得具有抗菌作用的植入物涂层材料。方法将硅灰石涂层浸入不同浓度(1%、5%、9%)硝酸银溶液中载银24 h。经扫描电镜观察涂层表面形貌、配套能谱仪分析表面物质成分、X射线衍射仪测定物相组成及原子吸收光谱仪检测涂层载银量等方法筛选合适的载银工艺。运用所选工艺制备载银涂层,并进行银离子缓释和抑菌环试验。结果随着硝酸银浓度的提高,涂层载银量增加。同时考虑载银量和成本因素,选择5%硝酸银溶液载银工艺进行后续研究。5%硝酸银溶液载银涂层在去离子水中银呈均匀释放50 d以上;抑菌环持续40 d以上,其最大直径为(6.00±0.25)mm,与未载银原始硅灰石涂层的抑菌环最大直径(0.23±0.34)mm比较,差异具有统计学意义(P<0.01)。结论硅灰石与硝酸银发生化学反应生成硅酸银,载银量随硝酸银浓度提高而增加。5%硝酸银溶液载银工艺所制备的载银硅灰石涂层具有良好的抗菌性能。
Objective To prepare the silver-loaded wollastonite coatings in order to obtain the bioactive implant material with antibacterial function. Methods Plasma sprayed wollastonite coatings were immersed in 1% , 5% and 9% AgNO3 solution for 24 h to load silver. They were evaluated by scanning electron microscopy, energy dispersive spectrometry, thin film X-ray diffraction and inductively coupled plasma-optical emission spectrometry to optimize the preparation process. The wollastonite coatings were prepared, the release rate of silver was measured and the antibacterial activity was examined. Results The amount of silver loaded to wollastonite coatings increased with AgNO3 concentration. The processing technique of silver loading with 5% AgNO3 solution was selected for subsequent research. A sustained release of silver was detected in deionized water, lasting for 50 days. The bacteria inhibition zone lasted for 40 days, and the maximal diameter of bacteria inhibition zone reached （6.00 ± 0.25） mm, significantly different from that without silver loading [ （ 0.23± 0.34） mm ] （P 〈0.01）. Conclusion Wollastonite has chemical reaction to AgNO3 and produces silver silicate. The amount of silver loaded to wollastonite coatings increases with AgNO3 concentration. The silver-loaded wollastonite coatings prepared by the processing technique of silver loading with 5% AgNO3 solution have a favourable antibacterial activity.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2008年第12期1499-1502,共4页
Journal of Shanghai Jiao tong University:Medical Science
关键词
银离子
硅灰石
涂层
抗菌性
silver ion
wollastonite
coating
antibacterial activity
