摘要
为了探讨镁离子对老年性小鼠年龄相关的学习记忆衰退的影响,将14月龄实验小鼠随机分为镁处理组和对照组,实验小鼠以10mg/kg的剂量饮用浓度为4mmol/L的MgCl2溶液60d之后,进行学习记忆能力行为学测试.结果显示,补充镁离子后,实验小鼠的活动量和探索能力没有发生明显改变.但是在新异物体识别实验中,与对照组相比,镁处理组鼠在新物体上探究的时间比例增高,显示了较强的识别记忆能力.此外在明暗箱被动回避实验中,镁处理组鼠逃避潜伏期长于对照组,亦表现出较强的恐惧记忆能力.由此认为,补充镁离子具有改善老年小鼠学习记忆能力的作用.
The experiment was designed to investigate the effect of magnesium on learning and memory ability in aged mice. Forty aged mice （14 months old） were divided into two groups randomly, magnesium-treated group and control group. In magnesium-treated group, mice were fed with the MgCl2 solution （concentration of solution= 4 mmol/L, dose= 10 mg/kg） for 60 days and then subjected to the novel object recognition test and passive avoidance task. No significant difference was found in locomotor activity and exploration between two groups. However, in the novel object recognition test, magnesium-treated mice showed significantly higher exploratory preference to the novel object than controls. In addition, compared to the controls, magnesiumtreated mice exhibited longer escape latency in the passive avoidance test, suggesting that magnesium-treated mice have better fear memory. These results indicate that magnesium can improve the ability of learning and memory in aged mice.
出处
《华东师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2008年第6期96-102,共7页
Journal of East China Normal University(Natural Science)
基金
国家科学与技术部973科研基金(2003CB716605)
国家自然科学基金(30670682)
关键词
镁离子
衰老
识别记忆
恐惧记忆
magnesium
ageing
recognition memory
fear memory
