摘要
目的应用高分辨率超声对早期2型糖尿病（T2DM）患者足背动脉形态学、血流动力学及血管内皮功能的改变进行观察。方法检测25例老年初发T2DM患者、35例非老年初发T2DM患者及35例老年健康者和30例非老年健康者足背动脉的变化，并进行统计学分析。结果（1）反应性充血时，老年T2DM组足背动脉内径变化百分率（10．52士2．79）％较老年对照组（15．43±4．69）％明显减低（P〈0．01），非老年T2DM组（12．89±4．68）％较非老年对照组（17．97±4．61）％明显减低（P〈0．01），老年T2DM组与非老年T2DM组比较亦有减低（P〈0．05）；含服硝酸甘油后，老年T2DM组（12．40士3．23）％较老年对照组（16．11±5．74）％明显减低（P〈0．01）。（2）T2DM组较同龄对照组足背动脉内－中膜厚度（IMT）明显增厚（P〈0．01），舒张早期反向血流峰值流速（PRV）和舒张末期血流速度（EDV）明显减低（P〈0．01），搏动指数（PI）减低（P〈0．05）；各组间收缩期峰值流速（PSV）的差异均无统计学意义（P〉0．05）。（3）T2DM组足背动脉PI与反应性充血时和舌下含服硝酸甘油后内径变化百分率呈显著正相关（相关系数分别为0．79和0．71，P〈0．01）。结论高分辨率超声检查可及早发现T2DM患者足背动脉形态学、血流动力学改变及血管内皮功能受损情况，可将其作为T2DM大血管并发症的首选检查方法。
Objective To evaluate the changes of morphology, hemodynamics and endothelial function of the dorsal artery of foot in patients with early-stage type 2 diabetic mellitus （T2DM） by high-resolution ultrasound. Methods The changes of morphology, homodynamics and endothelial function of the dorsal artery of foot were measured in 25 elderly and 35 non-elderly T2DM patients and 35 elderly and 30 non-elderly healthy persons. Results （1） The change percentage of inside diameter of foot dorsal artery under reactive hyperemia situation was obviously reduced in elderly T2DM patients compared with elderly healthy controls [ （10.52± 2.79） % vs. （ 15.43 ± 4.69） %, P〈0.01] and there was significant difference between non-elderly T2DM versus healthy persons （（12.89±_4.68） % vs. （17.97± 4.61） %, P〈0. 01], and it was lower in elderly versus non-elderly T2DM ones （P 〈 0.05）. The change percentage of inside diameter of foot dorsal artery was significantly lower in elderly T2DM versus healthy subjects after taning nitroglycerin [ （12.40± 3.23）% vs. （16.11±5.74）% , P〈0. 01]. （2） Compared with control groups, the intima-medial thickness （IMT） of dorsal artery of foot was thickened significantly, and the peak reverse velocity （PRV） in early diastole, the velocity in end diastole （EDV） and pulsatility index（PI） were reduced significantly in T2DM groups （P 〈 0.05）. The peak systolic velocity （PSV） had no significant differences among all the groups （P〉0.05）. （3） In T2DM groups, the PI was correlated positively with the change percentage of inside diameter of dorsal artery of foot under reactive hyperemia situation（r= 0.79, P〈0.01） and after having taken nitroglycerin （r=0. 71 , P〈0.01）, respectively. Conclusions The changes of morphology, hemodynamies and the injuries of endothelial function of the dorsal artery of foot can be detected in patients with early-stage T2DM by high-resolution ultrasound, which has clinical significance and a
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2008年第12期897-900,共4页
Chinese Journal of Geriatrics
基金
国家“十五”科技攻关项目（2004BA702B01）
关键词
糖尿病
2型
糖尿病足
内皮
血管
超声检查
Diabetic mellitus, type 2
Diabetic foot
Endothelium, vascular
Ultuasonography
