摘要
对１４６例慢性乙型肝炎、肝硬化和肝细胞癌标本作了免疫组化染色，观察其ｃ－ｅｒｂＢ－２癌基因蛋白（Ｐ１８５）及增殖细胞核抗原（ＰＣＮＡ）的表达情况，探讨他们在ＨＢＶ诱发ＨＣＣ过程中的作用和意义。结果：（１）在ＨＢＶ感染的慢性肝炎阶段已出现ｃ－ｅｒｂＢ－２Ｐ１８５和ＰＣＮＡ的异常表达，总阳性率分别为８７％和８．１％；（２）由慢性乙肝、肝硬化向肝细胞癌发展过程中，出现了ＰＣＮＡ表达逐渐升高，ｃ－ｅｒｂＢ－２Ｐ１８５逐渐下降的趋势：（３）证实了ｃ－ｅｒｂＢ－２１８５与肝病理炎症程度密切相关，而ＰＣＮＡ主要反映细胞增殖状态。由此可见，ＨＢＶ致ＨＣＣ过程是一个早以炎症为主，逐渐过度为细胞增殖为主的多阶段复杂过程。
Abstract The expression of c-erbB-2P185 Oncogene protein and PCNA were investigarted with immuno- histochemically in specimens from 146 cases of hepatitis B , cirrhosis and hepacocellular carcinoma. The re- sults , ( 1 )During chronic hepatitis B the total positive rates of c-erbB-2P185 and PCNA expression in chronic hepatitis B were 87% and 8.1%, respectively. (2)we found a increasing expression of PCNA and decreasing expression of c-erbB-2 oncogene proeein in che progression of chronic hepatiti. B , hepatic cirrhosis to HCC. (3)We also determined ,c-erbB-2P185 expression was closely related to bepatic inflammatory degree.
出处
《临床肝胆病杂志》
CAS
北大核心
1998年第1期26-29,共4页
Journal of Clinical Hepatology
