摘要
热休克蛋白（HSP）是由Ritossa从经受热刺激后的果蝇唾液腺中发现的，因此取名HSP。但随着后来的大量研究发现，HSP是一切生物体在许多应激状态下（如高温、重金属、缺氧、乙醇、病毒及细菌感染等）合成增加的一种在进化上高度保守的细胞应激蛋白。HSP作为分子伴侣在蛋白质的折叠、稳定性、合成等方面发挥重要作用。晶状体混浊即白内障，是世界上最常见的致盲原因之一。大量的研究表明，白内障的发生与自由基的产生、氧化损伤、晶状体蛋白比例改变及晶状体上皮细胞的凋亡有直接关系。近年来的研究表明，晶状体能表达一系列的HSP，它们对维持晶状体的稳定和透明起到关键作用。本文就HSP与白内障的发生研究现状作一综述。
The hot shock proteins （HSP） were discovered by Ritossa in the fruit fly salivary gland after heat stimulation, giving the name HSP. In following comprehansive studies, it was recovered that HSP was a group of highly conservative cell stress proteins in all organisms. HSP are expressed under many stress conditions, e. g. in the presence of high temperature, heavy metal, oxygen deficit, ethyl alcohol and viral or bacteriae infections, etc. HSP, as the molecular companion, play a vital role in the folding, stability and synthesis of the protein. The lens opacification （cataract） is one of most common causes of blindness in the world. Various studies indicate that the occurrence of cataract is directly related to free radical production, oxidized damage, changes of the proportion of lens protein and apoptosis of lens capsule epithelial cells, etc. Recent studies indicated that the lens expresses a series of HSP. They play a key role in maintaining the stability and transparency of the lens. This article is a summary of the relationship between the HSP and the occurrence of cataract.
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2008年第12期1141-1143,共3页
Chinese Journal of Ophthalmology
