摘要
目的探讨限制性输液对失血性休克大鼠血液系统的影响。方法制作大鼠失血性休克模型，采取限制性输液和大量输液两种不同输液方法复苏大鼠失血性休克，对比各组不同时间点血红蛋白（HGB）、红细胞比容（HCT）、凝血酶原（PT）、部分凝血活酶时间（APTT）以及纤维蛋白原含量（Fbg）的变化。结果休克模型120min后，与大量输液组比较，限制性输液组的HGB、HCT明显升高，分别为（142．5±12．3）g／L和（40．8±3．2）％（P均〈0．05），PT、APTT明显缩短，分别为（11．8±2．6）S和（57．2±8．1）S（P均〈0．05），Fbg含量显著增加，为（3．2±1．5）g/L（P〈0．05）。结论限制性输液可稳定HCT、维持HGB含量，缓解门和APTT时间的延长，阻止Fbg浓度的降低，是复苏失血性休克的理想方法。
Objective To investigate the effect of limited fluid resuscitation on blood system in white rats with hemorrhagic shock. Methods The model of hemorrhagic shock in white rats was established. The hemorrhagic shock of white rats was resuscitated by adopting two different transfusion means of limited fluid transfusion and traditional transfusion. The changes of HGB, HCT, PT, APTT and Fbg at various time points were compared between the two groups. Results At 120 min after the establishment of shock model, HGB, HCT and Fbg （ 142.5 ± 12.3 ） g/L, （40.8 ± 3.2 ） % and （3.2 ± 1.5 ） g/L, respectively） were significantly increased, while PT and APTT （ 11.8 ± 2.6） s and （57.2 ± 8.1 ） s were significantly shorter in the limited fluid transfusion group than those in the raditional resuscitation group （ P 〈 0. 05 ）. Conclusions Limited fluid resuscitation can significantly stabilize HCT, maintain HGB, ease the prolonged PT AND APTT times, and prevent the decrease of Fbg concentration. It is an ideal resuscitation means for the hemorrhagic shock.
出处
《中华现代护理杂志》
2008年第30期3154-3156,共3页
Chinese Journal of Modern Nursing
关键词
限制性输液
血液系统
失血性休克
Limited fluid resuscitation
Blood system
Hemorrhagic shock
